| 局部大剂量灌注治疗上颌窦癌的临床研究 |
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| 引用本文： | 赵锦龙,曹振远,刘增尧,冷久成. 局部大剂量灌注治疗上颌窦癌的临床研究[J]. 黑龙江医学, 2010, 34(6): 456-458. DOI: 10.3969/j.issn.1004-5775.2010.06.022 |
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| 作者姓名： | 赵锦龙 曹振远 刘增尧 冷久成 |
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| 作者单位： | 哈尔滨医科大学附属第一医院介入科,黑龙江,哈尔滨,150001;哈尔滨医科大学附属第一医院介入科,黑龙江,哈尔滨,150001;哈尔滨医科大学附属第一医院介入科,黑龙江,哈尔滨,150001;哈尔滨医科大学附属第一医院介入科,黑龙江,哈尔滨,150001 |
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| 摘 要： | 目的讨论局部大剂量灌注治疗上颌窦癌的临床疗效。方法对20例晚期上颌窦癌患者行动脉内大剂量顺铂(DDP)(200 mg/mg2)灌注化疗,同时静点硫代硫酸钠(STS),对结果进行回顾性分析。结果 20例患者有效率为100%,术后肿瘤明显缩小,除恶心等胃肠道症状外,无严重并发症发生。结论上颌窦癌的局部大剂量灌注治疗是安全可靠的,提高了晚期患者的生存质量,可作为晚期上颌窦癌患者选择的治疗方法之一。
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| 关 键 词： | 上颌窦癌 大剂量灌注治疗 顺铂 硫代硫酸钠 |
The Clinical Study of High-dose Intra-arteral Infusion Cisplatin for Maxillary Sinus Carcinoma |
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| Affiliation: | ZHAO Jin-long,CAO Zhen-yuan,LIU Zeng-yao,et al.(Department of Interventional,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,CHINA) |
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| Abstract: | Objective To discuss the curative effect of high-dose intra-arterial infusion cisplatin for maxillary sinus carcinoma.Methods 20 cases with clinical advanced maxillary sinus carcinoma received intra-arterial chemotherapy with cisplatin（DDP）,at the same time intra-venous infusion with thiosulfas（STS） for rescue.DDP at 200 mg/m^2.Results All the patients had a complate response to arterial insufion chemotherapy.The tumor deflated after therapy obviously.Minor side effects,such as nausea,vomiting,and reactive mucositis,were controlled by medication.No major neurological or systemic complications occurred.Conclusion The high-dose intra-arterial infusion cisplatin for maxillary sinus carsinoma is safe and reliable,can be a selective therapy for advanced maxillary sinus carcinoma. |
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| Keywords: | Maxillary sinus carcinoma High-dose intra-arterial infusion chemotherapy Cisplatin Thiosulfas |
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