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良性前列腺增生与代谢综合征代谢因素相关性研究
引用本文:王蕾蕾,王建龙,朱玲. 良性前列腺增生与代谢综合征代谢因素相关性研究[J]. 中华健康管理学杂志, 2012, 0(3): 174-177
作者姓名:王蕾蕾  王建龙  朱玲
作者单位:[1]卫生部北京医院特需医疗部,100730 [2]卫生部北京医院泌尿外科,100730
基金项目:基金项目:国家自然科学基金资助项目(C140406)
摘    要:目的通过对男性患者的相关查体指标分析,探讨男性良性前列腺增生(BPH)患者的高危代谢因素。方法男性患者738例,分为无BPH及无代谢综合征(MS)者组(A组),有BPH及无MS者组(B组),无BPH及有MS者组(C组),有BPH及有MS者组(D组)。检测体质指数(BMI)、收缩压、舒张压、空腹血糖(FBG)、血总胆固醇(TC)、血三酰甘油(TG)、低密度脂蛋白胆固醇(LDL—C)、高密度脂蛋白胆固醇(HDL—C)、血谷丙转氨酶(ALT)、血总胆红素(TB)、血肌酐、血尿素、糖化血红蛋白(HbA1c)、血尿酸等指标。结果B组年龄、BMI、收缩压、舒张压、TG、TC、LDL—C及HbA1c水平均显著高于A组,而HDL—C显著低于A组(P〈0.05);D组年龄、BMI、收缩压、舒张压、TG、TC、LDL—C、血尿酸及HbAlc水平均显著高于C组,而HDL—C显著低于C组(P〈0.05)。多因素logistic回归分析显示,年龄60岁以上(DR:4.432,95%CI:1.331~14.759)、超重或肥胖(OR:228.165,95%CI:21.932—2373.724)、高血压(OR:33.350,95%CI:10.221~108.824)、高FBG(OR:131.669,95%CI:21.033—824.279)、高TG(OR:53.500,95%CI:11.547~247.889)是BPH合并MS独立危险因素。结论BPH与MS关系密切,老龄、超重或肥胖、高血压、高TG、高FBG等代谢异常是BPH合并MS的危险因素。

关 键 词:前列腺增生  代谢综合征X  危险因素

Relationship between benign prostate hyperplasia and metabolic syndrome
WANG Lei-lei,WANG Jian-long,ZHU Ling. Relationship between benign prostate hyperplasia and metabolic syndrome[J]. Chinese Journal of Health Management, 2012, 0(3): 174-177
Authors:WANG Lei-lei  WANG Jian-long  ZHU Ling
Affiliation:. VIP Department,Beijing Hospital,Ministry of Health,Beijing 100730,China
Abstract:Objective To investigate the risk factors of benign prostate hyperplasia (BPH). Methods A total of 738 male subjects were assigned to the non-BPH + non-metabolic syndrome (MS) group ( group A), BPH + non-MS group ( group B), MS + non-BPH group ( group C), and BPH + MS group (group D). Body mass index( BM1), systolic blood pressure (SBP) , diastolic blood pressure (DBP) ,fasting blood glucose ( FBG ), total cholesterol ( TC ), triglyceride ( TG ), low-density lipoprotein cholesterol ( LDL-C), high-density lipoproteiu cholesterol ( HDL-C ) , glycosylated alanine aminotransferase ( ALT ), serum creatinine, hemoglobin (HbA1 c ), and serum uric acid (UA) were measured. Results In comparison with group A, age, BMI, SBP, DBP, TG, TC, LDL-C and HbAlc of group B were significantly increased, although HDL-C was significantly reduced. Age, BMI, SBP, DBP, TG, TC, LDL-C, UA and HbA1 c of group D were significantly higher than those of group C, while HDL-C was relatively lower. In multivariate logistic regression analysis, 〉 60 years [ odds ratio (OR) = 4.432, 95% confidence interval (CI) 1. 331 to 14. 759 ], overweight/obese ( OR = 228. 165,95% CI 21. 932 to 2373. 724), hypertension ( OR = 33. 350, 95 % CI 10. 221 to 108. 824), higher FBG ( OR = 131. 669,95 % CI 21. 033 to 824. 279 ), and higher TG ( OR = 53. 500,95% CI 11. 547 to 247. 889) were independent risk factors of BPH with MS. Conclusion Our data suggest a close relationship between BPH and MS. Elderly, overweight/obesity, and higher blood pressure,TC or FBG might be the risk factors of BPH and MS.
Keywords:Prostatic hyperplasia  Metabolic syndrome X  Risk factors
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