| 速度向量成像评价胰岛素对糖尿病心肌病大鼠心肌功能的影响 |
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| 引用本文： | 张展,赵雯,贺建国,张军.速度向量成像评价胰岛素对糖尿病心肌病大鼠心肌功能的影响[J].中国医学影像技术,2011,27(5):869-872. |
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| 作者姓名： | 张展 赵雯 贺建国 张军 |
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| 作者单位： | 第四军医大学西京医院超声诊断科,陕西,西安,710032 |
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| 基金项目： | 国家自然科学基金(30870714)。 |
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| 摘 要： | 目的 应用VVI定量评价胰岛素治疗后糖尿病心肌病大鼠心肌功能的变化。 方法 30只雄性SD大鼠,随机分为糖尿病组(DM组)、胰岛素治疗组(INS组)和正常对照组(CON组),每组10只。腹腔注射链脲佐菌素建立糖尿病模型后,INS组给予胰岛素皮下注射(6 U/kg体质量),每日一次。于造模成功12周后开胸,取左心室短轴图像进行VVI分析,并取心肌组织行透射电镜观察。 结果 与DM组比较,INS组收缩和舒张期径向峰值速度(Vs、Vd)、径向峰值应变(Sr)、收缩期径向峰值应变率(收缩期SRr)以及切向峰值应变(Sc)、收缩和舒张期切向峰值应变率(收缩期SRc、舒张期SRc)均较高(P＜0.05);舒张期径向峰值应变率(舒张期SRr)与DM组差异无统计学意义(P＞0.05)。与CON组比较,INS组除舒张期SRr、收缩期SRc、舒张期SRc较低(P＜0.05)外,余指标与CON组差异无统计学意义(P＞0.05)。 结论 胰岛素能明显改善糖尿病心肌病大鼠的心肌功能;VVI应变率指标在评估糖尿病心肌病治疗疗效及预后方面起着重要作用。
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| 关 键 词： | 胰岛素 糖尿病 心肌病 速度向量成像 |
| 收稿时间： | 2010/12/27 0:00:00 |
| 修稿时间： | 2011/1/26 0:00:00 |
Evaluation on the effect of insulin on myocardial function of diabetic cardiomyopathy in rats with velocity vector imaging |
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| ZHANG Zhan,ZHAO Wen,HE Jian-guo and ZHANG Jun.Evaluation on the effect of insulin on myocardial function of diabetic cardiomyopathy in rats with velocity vector imaging[J].Chinese Journal of Medical Imaging Technology,2011,27(5):869-872. |
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| Authors: | ZHANG Zhan ZHAO Wen HE Jian-guo and ZHANG Jun |
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| Institution: | Department of Ultrasonic Diagnosis, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China;Department of Ultrasonic Diagnosis, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China;Department of Ultrasonic Diagnosis, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China;Department of Ultrasonic Diagnosis, Xijing Hospital, the Fourth Military Medical University, Xi'an 710032, China |
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| Abstract: | Objective To evaluate the change of myocardial function of diabetic cardiomyopathy in rats with insulin treatment using velocity vector imaging(VVI) technology.Methods Thirty rats were divided into 3 groups: Diabetes mellitus group(DM,n=10),insulin-treatment group(INS,n=10) and control group(CON,n=10).DM models were established through intraperitoneal injection of streptozotocin.Rats in INS group were given insulin hypodermic injection at dose of 6 U/kg once a day ever since the DM models were established.A... |
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| Keywords: | Insulin Diabetes mellitus Cardiomyopathies Velocity vector imaging |
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