慢性乙肝患者血清NO与肝纤维化关系探讨

目的:研究慢性乙肝患者(CHB)血清一氧化氮(NO)、透明质酸(HA)、层粘蛋白(LA),IV型胶原(C-IV)血清水平的变化,探讨其在肝纤维化机制中的作用.方法:应用比色法、放免法测定107例CHB、20例健康成人血清NO、HA、LN、C-IV水平.结果:CHB轻、中、重度及肝硬化患者血清NO水平均显著高于对照组(P＜0.01),并随着肝损害和肝纤维化程度的加重而升高,血清NO水平与血清HA、LN、C-IV水平呈相关(P＜0.01).结论:NO不仅与肝损伤密切相关,而且与肝纤维化程度相关,NO参与病毒性肝炎及肝纤维化的病理过程,检测NO有助于判断慢性肝病肝纤维化的程度.

Research the Relation of Hepatic Fibrosis with Serum NO in Patients with Chronic Hepatitis B

Objective: To discuss the changes of serum nitric(NO),hyalopasm acid(HA),laminin(LN)and collagen type IV(C-IV) level on hepatic fibrosis mechanism by studying them in patients with chronic hepatitis B(CHB).Method: The concentrations of serum NO,HA,LN,C-IV in 107 patients with CHB and 20 healthy adult were measured by colorimetry and radioimmunoassay.Result: The levels of serum NO in mild CHB group moderate CHB group,severe CHB group and liver cirrhosis(LC) group were higher significant than that in the control(p<0.01),and change with the degree of hepatic injury and fibrosis,The level of serum NO was positive correlated with the levels of serum HA,LN and C-IV(p<0.01).Conclusion: Serum NO is corresponding with not only hepatic injury,but also with hepatic fibrosis degree,NO takes,NO takes part in pathological process of viral hepatitis and hepatic fibrosis Testing the serum NO contributes to evaluating the hepatic fibrosis degree in patients with chronic hepatic disease