基质金属蛋白酶-9在大肠癌中的表达及其与血管生成的相关性

目的]探讨基质金属蛋白酶-9（MMP-9）在大肠癌中的表达及其与血管生成关系的临床意义。方法]应用免疫组化SP法检测108例大肠癌组织中MMP-9、血管内皮生长因子（VEGF）的表达以及微血管密度（MVD）。结果]MMP-9、VEGF的表达和MVD值与肿瘤分化、淋巴结转移、Dukes分期明显相关；MMP-9、VEGF阳性表达组的MVD值显著高于阴性组；MMP-9与VEGF在大肠癌组织中表达呈正相关。结论]MMP-9与大肠癌血管生成有关，检测MMP-9的表达可作为反映大肠癌侵袭和转移的生物学指标。

Expression of Matrix Metalloproteinases-9 and Its Relationship with Angiogenesis in Colorectal Carcinoma

Purpose] To study the clinical significance and the relationship between the expression of matrix metalloproteinases-9 (MMP-9) and angiogenesis in colorectal carcinoma. Methods] The expressions of MMP-9, vascular endothelial growth factor (VEGF) and microvessel density (MVD) in 108 cases with colorectal cancer were detected by S-P immunohistochemical method. Results] The expressions of MMP-9 and VEGF were significantly correlated with the numbers of MVD and the differentiation, lymph node metastasis and Dukes stage in colorectal cancer. The value of MVD in cases with the positive expressions of MMP-9 and VEGF was higher than that in cases with the negative ones. There was a positive correlation between expressions of MMP-9 and VEGF in colorectal carcinoma. Conclusion] There is a close relationship between the expression of MMP-9 and angiogenesis in colorectal carcinoma. The expression of MMP-9 can be used as a biological marker for cancer agreesiveness and metastasis in colorectal carcinoma.