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| Cytomegalovirus colitis in a patient with Behcet’s disease receiving tumor necrosis factor alpha inhibitory treatment | |
| 引用本文： | Sari I,Birlik M,Gonen C,Akar S,Gurel D,Onen F,Akkoc N. Cytomegalovirus colitis in a patient with Behcet’s disease receiving tumor necrosis factor alpha inhibitory treatment[J]. World journal of gastroenterology : WJG, 2008, 14(18): 2912-2914. DOI: 10.3748/wjg.14.2912 |
| 作者姓名： | Sari I Birlik M Gonen C Akar S Gurel D Onen F Akkoc N |
| 作者单位： | Ismail Sari（Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir 35340, Turkey） ;Merih Birlik（Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir 35340, Turkey） ;Can Gonen（Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir 35340, Turkey） ;Server Akar（Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir 35340, Turkey） ;Duygu Gurel（Department of Pathology, Dokuz Eylul University School of Medicine, Izmir 35340, Turkey） ;Fatos Onen（Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir 35340, Turkey） ;Nurullah Akkoc（Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir 35340, Turkey） ; |
| 摘 要： | Anti-tumor necrosis factor alpha （TNF-α） inhibitors are effective in the treatment of various inflammatory rheumatic conditions. Increased risks of serious infections are the major issues concerning the long-term safety of these agents. We present a case of a young male Behcet’s patient whose disease was complicated by cytomegalovirus （CMV） colitis. Colitis started 10 d after the third Infliximab dose and responded to the cessation of TNF blocking treatment and administration of ganciclovir. Tumor necrosis factor alpha and interferon gamma act at several levels in combating viral infections.CMV infections should be kept in mind and included in the differential diagnosis of severe gastrointestinal symptoms in patients receiving anti-TNF agents. |
| 关 键 词： | 肿瘤坏死因子α抑制剂 巨细胞病毒 大肠炎 病毒感染 |
| 收稿时间： | 2008-01-28 |
Cytomegalovirus colitis in a patient with Behcet's disease receiving tumor necrosis factor alpha inhibitory treatment |
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| Sari Ismail,Birlik Merih,Gonen Can,Akar Servet,Gurel Duygu,Onen Fatos,Akkoc Nurullah. Cytomegalovirus colitis in a patient with Behcet's disease receiving tumor necrosis factor alpha inhibitory treatment[J]. World journal of gastroenterology : WJG, 2008, 14(18): 2912-2914. DOI: 10.3748/wjg.14.2912 | |
| Authors: | Sari Ismail Birlik Merih Gonen Can Akar Servet Gurel Duygu Onen Fatos Akkoc Nurullah |
| Affiliation: | 1. Division of Rheumatology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir 35340, Turkey 2. Division of Gastroenterology, Department of Internal Medicine, Dokuz Eylul University School of Medicine, Izmir 35340, Turkey 3. Department of Pathology, Dokuz Eylul University School of Medicine, Izmir 35340, Turkey |
| Abstract: | Anti-tumor necrosis factor alpha (TNF-α) inhibitors are effective in the treatment of various inflammatory rheumatic conditions. Increased risks of serious infections are the major issues concerning the long-term safety of these agents. We present a case of a young male Behcet's patient whose disease was complicated by cytomegalovirus (CMV) colitis. Colitis started 10 d after the third Infliximab dose and responded to the cessation of TNF blocking treatment and administration of ganciclovir. Tumor necrosis factor alpha and interferon gamma act at several levels in combating viral infections.CMV infections should be kept in mind and included in the differential diagnosis of severe gastrointestinal symptoms in patients receiving anti-TNF agents. |
| Keywords: | Tumor necrosis factor alpha inhibitors Adverse effects Virus diseases |
| 本文献已被 维普 万方数据 PubMed 等数据库收录！ | |