甲状腺激素缺乏对大鼠胸腺CK19阳性上皮细胞的影响

目的探讨甲状腺激素缺乏对大鼠胸腺CK19^ 上皮细胞的影响。方法将断乳1月龄的Wistar大鼠分为2组：正常组饲以正常饲料，饮用自来水；低碘组饲以低碘饲料，饮用去离子水。实验3个月及6个月后，测定各组大鼠的胸腺指数、血清甲状腺激素及胸腺CK19^ 上皮细胞的体密度和面数密度。结果实验3个月后，低碘组大鼠的胸腺指数、T4显著降低，而CK19^ 上皮细胞的体密度和面数密度未见明显变化；实验6个月后，低碘组大鼠的T3、T4显著降低，胸腺CK19^ 上皮细胞的体密度的面数密度显著降低。结论甲状腺激素缺乏可使大鼠胸腺严重退化，CK19^ 上皮细胞减少。

Effect of thyroid hormones deficiency on CK19+ thymic epithelial cells

Objectives To study the influence of thymic CK19~+ epithelial cells in condition of thyroid hormones deficiency.Methods Wistar rats,1 month after stopping laction,were divided into two groups.Normal group was fed with normal-iodine diet and a tap water.Low iodine group was fed with low-iodine diet and a deionic water.Three months and six months later respectively,we measure thymic index,thyroid hormones in serum and volume density(Vv)and numerical density on area(N_A)of CK19~+ thymic epithelial cells.Results Three months later,thymic index and T_4 were decreased dramatically in low iodine group.However,the significant changes in volume density and numerical density on area of thymic CK19~+ epithelial cells were not observed.Six months later,T_3 T_4 and volume density and numerical density on area of thymic CK19~+ epithelial cells were decreased obviously in low iodine group.Conclusions Thymus degeneration and decrease of CK19~+ thymic epithelial cells were demonstrated in iodine deficiency rats,possibly due to hypothyroidism.