| 联合应用东莨菪碱对家兔急性实验性肝性脑病的治疗作用 |
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| 引用本文： | 袁文丹,杨芳.联合应用东莨菪碱对家兔急性实验性肝性脑病的治疗作用[J].中国航天工业医药,2010(8):33-34. |
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| 作者姓名： | 袁文丹 杨芳 |
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| 作者单位： | [1]山东滨州医学院基础学院,山东烟台264003 [2]山东聊城职业学院,山东烟台264003 |
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| 摘 要： | 目的探讨东莨菪碱对家兔急性实验性肝性脑病的治疗作用及其可能机制,为肝性脑病的临床药物治疗提供实验依据。方法复制急性肝性脑病的动物模型,观察东莨菪碱对家兔抽搐情况、血氨变化以及脂质过氧化损伤的影响。结果东莨菪碱治疗组家兔抽搐症状减轻,血氨降低,MDA含量降低,且可防止SOD减少（P〈0.01）。结论东莨菪碱有明显镇静、止痉作用,并有降血氨作用,对肝脏的脂质过氧化损伤具有部分保护作用。
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| 关 键 词： | 东莨菪碱 肝性脑病 血氨 抽搐症状 脂质过氧化 |
The therapeutical effect of hyoscine hydrobromide combined on experimental hepatic encephalopathy of rabbit |
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| Authors: | Yuan Wendan Yang Fang |
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| Institution: | .Binzhou Medical College of Shandong,Yantai 264003 |
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| Abstract: | Objective To investigate the effect of hyoscine hydrobromide on experimental hepatic encephalopathy of rabbits,and to find potential mechanism,and to provide the experimental evidences for combined therapy.Methods Made the model of hepatic encephalopathy by resection operation,Spasm of rabbits was observed,blood ammonia and lipid peroxidation were detected.Results By using hyoscine hydrobromide,reducing of blood ammonia and lipid peroxidation were detected,and depressing of spasm was detected too.Conclusion Hyoscine hydrobromide had obviously inhibition effect on conscious-sedation and spasm,and reduce blood ammonia,and improve the protective function of liver on lipid peroxidation. |
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| Keywords: | Hyoscine hydrobromide Hepatic encephalopathy Blood ammonia Spasm Lipid peroxidation |
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