多烯磷脂酰胆碱联合异甘草酸镁治疗药物性肝损害疗效观察

目的观察多烯磷脂酰胆碱联合异甘草酸镁治疗药物性肝损害的临床疗效。方法观察组以多烯磷脂酰胆碱联合异甘草酸镁治疗药物性肝损害128例,对照组以甘草酸二胺治疗药物性肝损害92例,治疗结束后观察其症状、体征以及肝功能的变化。结果 2周后两组患者丙氨酸氨基转移酶、天门冬酸氨基转移酶及总胆红素较治疗前均明显下降,组内差异有统计学意义（P〈0.05）,两组之间差异无统计学意义（P〉0.05）,观察组显效率（75.78%）高于对照组显效率（64.13%）,差异有统计学意义（P〈0.05）。结论多烯磷脂酰胆碱联合异甘草酸镁可明显改善药物性肝损害的临床症状和肝功能指标,且显效率高,不良反应少。

Effect of polyene phosphatidylcholine and magnesium isoglycyrrhizinate in the treatment of the drug-induced liver injury

Objective To explore the effective therapy for therapeutic drug-induced liver injury of polyene phosphatidyl-choline combined magnesium isoglycyrrhizinate. Methods A total of 220 patients with drug-induced liver injury were randomly assigned to receive polyene phosphatidylcholine combined magnesium isoglycyrrhizinate（128 cases,observation group） or diammonium glycyrrhizinate for injection（92 cases,control group） ivgtt qd for 2 consecutive weeks. Results After the treatment for 2 weeks,levels of alanine aminotransferase（ALT）,aspartate aminotransferase（AST） and total bilirubin（TB） decreased in both groups（P0.05）,but there was no significant difference between two groups（P0.05）.The rate of marked improvement （75.78% in treatment group and 64.13%in control group） was significant different（P0.05）. Conclusion Polyene phosphatidylcholine and magnesium isoglycyrrhizinate is effective in the treatment of the drug-induced liver injury.