测定血清TRAb、HA在Graves眼病中的临床意义 |
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引用本文: | 韦华,李凤玲,方文珠,吴明清.测定血清TRAb、HA在Graves眼病中的临床意义[J].中国航天工业医药,2010(7). |
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作者姓名: | 韦华 李凤玲 方文珠 吴明清 |
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作者单位: | 广西右江民族医学院附属医院内分泌科 广西右江民族医学院附属医院核医学科 广西右江民族医学院附属医院眼科 |
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摘 要: | 目的探讨促甲状腺素受体抗体(TRAb),透明质酸(HA)在Graves眼病(GO)发病机制中的作用。方法采用放射免疫分析法、放射受体分析法测定Graves眼病(GO)患者98例(根据甲状腺功能状态分为GO1组46例、GO2组52例)、Graves病无眼病(NGO)患者50例和正常对照组30例血清FT3、FT4、s-TSH、TRAb和血清HA水平。结果①GO1和NGO组的TRAb浓度明显高于正常对照组(P<0.01),GO1和GO2组HA浓度明显高于正常对照组(P<0.01);②活动性的GO患者TRAb浓度与非活动性比较无差异(P>0.05),而HA明显高于非活动性且有统计学意义(P<0.01);③Graves病患者血FT3与TRAb浓度呈正相关,相关系数为0.21(P<0.01)。HA浓度与血甲状腺激素和TSH均无明显相关性。结论 TRAb参与GD的发生,HA在GO的发病中起相关作用。
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关 键 词: | Graves眼病 Graves病 促甲状腺素受体抗体 透明质酸 |
Serum detection of TRAb and HA in patients with Graves ophthalmopathy and their clinical significance |
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Institution: | Wei Hua; Li Fengling; Fang Wenzhu; et al. Department of Endocrine; Affiliated Hospital of Youjiang Medical College for Nationalities; Baise; Guangxi 533000; |
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Abstract: | Objective To investigate the value of serum thyrotropin receptor antibody (TRAb), hyaluronic acid (HA) in patients with Graves ophthalmopathy. Methods Using radioimmunoassay,serum values of FT3,FT4,s-TSH,TRAb and HA were detected in 98 patients with Graves’ophthalmopathy (GO,this group subdivided into GO1,GO2), 50 patients with no Graves’ ophthalmopathy (NGO) and 30 normal controls. Results ①Serum TRAb in GO1 group and NGO group were significantly higher than in normal control group(P<0.01), Serum HA in ... |
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Keywords: | Graves ophthalmopathy Graves disease Thyrotropin receptor antibody Hyaluronic acid |
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