IL-17在卵巢上皮性癌中的表达及临床意义

目的探讨白细胞介素17（IL-17）在卵巢上皮性癌组织中的表达及临床意义。方法采用免疫组织化学SP法检测25例正常卵巢组织、25例良性卵巢肿瘤与25例卵巢上皮性癌原发灶中IL-17蛋白表达,酶联免疫吸附试验检测患者术前、术后1周外周血中IL-17水平。结果卵巢癌患者癌组织中IL-17表达强度和外周血中IL-17水平均明显高于正常对照组和卵巢良性肿瘤组（P〈0.01）;卵巢癌患者术后血清IL-17水平比术前显著下降（P〈0.01）。术前血清IL-17水平在卵巢癌组织学类型中无显著性差异（P〉0.05）;Ⅲ～Ⅳ期卵巢癌患者术前血清IL-17水平显著高于Ⅰ～Ⅱ期患者,差异有统计学意义（P〈0.05）;高中分化卵巢癌患者术前血清IL-17水平显著低于低分化患者,差异有统计学意义（P〈0.05）。结论上皮性卵巢癌组织中IL-17表达上调,IL-17在上皮性卵巢癌的生长和转移过程中发挥重要作用。

Expression and clinical significance of IL-17 in epithelial ovarian carcinoma

Objective To investigate the expression of IL-17 in patients with epithelial ovarian cancer （EOC） and its clinical significance.Methods 25 epithelial ovarian cancers,25 benign ovarian tumors and 25 patients with uterus myoma at surgery in synchronization as controls were enrolled in this study.Use the immunohistochemistry to determine the intensity of IL-17 staining in tissue samples,and examine the serum level before operation and one week after operation respectively by ELISA.Results The intensity of IL-17 staining and the serum IL-17 level in EOCs was obviously higher than that in the control group and benign tumors （P〈0.01）.Postoperative IL-17 level in EOCs was significantly lower than preoperative level （P 0.01）.There was no significant difference of preoperative serum IL-17 level in histological type （P〈0.05）.The preoperative serum IL-17 level in stage Ⅲ～Ⅳ was higher than that in stage Ⅰ～Ⅱ （P〈0.05）.The preoperative serum IL-17 median level in G1～G2 was lower than that in G3 with significant difference （P〈0.05）.Conclusion IL-17 expression is up-regulated in EOC.It plays an important role in tumor growth and metastasis of EOC.