| 肝癌患者血清及肿瘤组织VEGF的表达及意义 |
| |
| 引用本文： | 钟崇,苏小康,韦玮,李惠东,郭荣平. 肝癌患者血清及肿瘤组织VEGF的表达及意义[J]. 中国航天工业医药, 2010, 0(7) |
| |
| 作者姓名： | 钟崇 苏小康 韦玮 李惠东 郭荣平 |
| |
| 作者单位： | 广州中医药大学第一附属医院肝胆外科 中山大学肿瘤防治中心肝胆科 |
| |
| 基金项目： | 2010年广州中医药大学中医药科研创新基金项目(项目编号:10CX019) |
| |
| 摘 要： | 目的探讨肝癌患者血清及组织中VEGF的表达情况及其在预测肝癌侵袭和患者预后的意义。方法将64例手术切除肝细胞肝癌患者分为复发组(n=42)与未复发组(n=22),采用酶联免疫吸附和免疫组化方法检测患者的术前血清及标本中VEGF的表达情况,分析其与临床病理指标关系并进行复发风险多因素分析。结果血清VEGF的浓度为334.50±247.62pg/ml,明显高于健康对照组(P<0.01)。复发组血清VEGF浓度明显高于未复发组(P<0.05)。已复发组VEGF的阳性率为85.7%,未复发组为54.5%(P<0.05)。VEGF阴性组的1、2、3年无瘤生存率分别为81.3%、68.8%及62.5%,VEGF阳性组的分别为52.1%、33.3%及29.1%(P<0.01)。多因素分析表明术前播散结节、微转移灶及VEGF的表达水平是影响预后的危险因素。结论肝癌患者血清及肿瘤组织中VEGF的表达水平明显升高,与肝癌患者的术后复发相关,可预测患者的复发风险。
|
| 关 键 词： | 肝肿瘤 VEGF 酶联免疫吸附试验 免疫组化 预后 |
The expression and value of VEGF in serum and tumor tissue in HCC patients |
| |
| Affiliation: | Zhong Chong; Su Xiaokang; Wei Wei; et al. The First Affiliated Hospital; Guangzhou Traditional Chinese Medicine University; Guangdong 510405; |
| |
| Abstract: | Objective To investigate the expression and clinical value of VEGF in estimating the invasion and prognosis of HCC. Methods The expression of VEGF in 64 serum and resection specimens of HCC, confirmed by pathology, was detected by enzyme-linked immunosorbent assay (ELISA) and immunohistochemistry. Correlations of the expression of VEGF to clinicopathologic features were analyzed. Cox regression model was used to analyze the recurrence and VEGF after hepatectomy. Results The serum level of VEGF in HCC patien... |
| |
| Keywords: | Liver neoplasm VEGF Enzyme-linked immunosorbent assay Immunohistochemistry Prognosis |
| 本文献已被 维普 等数据库收录！ |
