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CANINE CORONARY BLOOD FLOW RESPONSES TO HYPOXAEMIA: THE INFLUENCE OF HALOTHANE |
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| Authors: | VANCE, J. P. BROWN, D. M. SMITH, G. THORBURN, J. |
| Affiliation: | Division of Anaesthesia, Royal Infirmary Glasgow G4 0SF University Department of Anaesthesia, Western Infirmary Glasgow G11 6NT Division of Anaesthesia, Western Infirmary Glasgow G11 6NT |
| Abstract: | Electromagnetic flow meters were used to measure blood flowin the coronary and pulmonary arteries of six anaesthetizeddogs following thoracotomy. Halothane 1% (v//v) caused a reductionin arterial pressure, coronary artery flow, cardiac output andmyocardial and total body oxygen consumption and an increasein coronary vascular resistance. Hypoxaemia caused large increasesin coronary artery flow during both cardiac systole and diastole,but not until PaO22 was less than 5.3 kPa. This response wasnot influenced by the presence of halothane. Although myocardialoxygen availability and consumption were maintained during hypoxaemia,total body oxygen availability and consumption were markedlyreduced. |
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