| 三棱和莪术对肺纤维化大鼠肺组织细胞凋亡的影响 |
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| 引用本文： | 王英豪,姚欣,邱颂平,杨素芳,周春权.三棱和莪术对肺纤维化大鼠肺组织细胞凋亡的影响[J].福建中医学院学报,2011,21(4):28-30,37. |
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| 作者姓名： | 王英豪 姚欣 邱颂平 杨素芳 周春权 |
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| 作者单位： | 1. 福建中医药大学药学院,福建福州,350108
2. 福建省中医药研究院,福建福州,350003 |
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| 基金项目： | 福建省高校中西医结合基础重点实验室开放课题基金(CKJ2008011); 陈可冀中西医结合发展基金资助项目(ZXY2008007); 福建省教育厅科技资助项目(JA05277); 福建省卫生厅青年科研项目(2006-2-31) |
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| 摘 要： | 观察三棱和莪术对肺纤维化大鼠肺形态学及肺组织细胞凋亡的影响. 方法大鼠气管内注入博来霉素(5 mg/kg)造模,随机分为空白组、模型组、三棱和莪术高剂量组(1 g/mL)、低剂量组(0.5 g/mL)及泼尼松组(15 mg/kg),分别于用药后第28天处死大鼠,观察肺纤维化病理变化,血浆单核细胞趋化活化因子MCP-1的...
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| 关 键 词： | 三棱 莪术 肺纤维化 细胞凋亡 |
Effects of Rhizoma Sparganii and Rhizoma Curcumae on Apoptosis of Lung Tissue in Rats with Pulmonary Interstitial Fibrosis |
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| WANG Yinghao,YAO Xin,QIU Songping,et al.Effects of Rhizoma Sparganii and Rhizoma Curcumae on Apoptosis of Lung Tissue in Rats with Pulmonary Interstitial Fibrosis[J].Journal of Fujian College of Traditional Chinese Medicine,2011,21(4):28-30,37. |
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| Authors: | WANG Yinghao YAO Xin QIU Songping |
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| Institution: | WANG Yinghao1,YAO Xin2,QIU Songping1,et al(1.College of Pharmacy,FUTCM,Fuzhou,Fujian 350108,China,2.Fujian Academy of TCM and Pharmacy,Fujian 350003,China) |
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| Abstract: | Objective To observe the effect of Rhizoma Sparganii and Rhizoma Curcumae on pulmonary morphology and lung tissue apoptosis in rats with pulmonary interstitial fibrosis.Methods Rats were randomly divided into blank group,model group,Rhizoma Sparganii and Rhizoma Curcumae high-dose group,Rhizoma Sparganii and Rhizoma Curcumae low-dose group and prednisone group.The models were established with intratracheal injection of Bleomycin,the drugs were given daily from the second day after successful modeling,and ra... |
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| Keywords: | Rhizoma Sparganii Rhizoma Curcumae fibrosis of lung apoptosis |
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