| 粗叶悬钩子总生物碱对非酒精性脂肪肝的抗氧化作用 |
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| 引用本文： | 赵锦燕,郑玉清,郑海音,钟晓勇,伍娟,洪振丰. 粗叶悬钩子总生物碱对非酒精性脂肪肝的抗氧化作用[J]. 福建中医学院学报, 2011, 0(5): 15-17 |
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| 作者姓名： | 赵锦燕 郑玉清 郑海音 钟晓勇 伍娟 洪振丰 |
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| 作者单位： | 1. 福建中医药大学中西医结合研究院,福建福州,350108
2. 福建中医药大学中西医结合学院,福建福州,350108 |
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| 基金项目： | 福建省自然科学基金资助课题(2010J01194); 福建省科技厅重点课题(2009I0013); 福建省教育厅资助课题(JA09138) |
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| 摘 要： | 目的 探讨粗叶悬钩子总生物碱对模型大鼠的抗氧化作用. 方法SD大鼠30只,随机分为空白对照组、模型组、粗叶悬钩子总生物碱组,高脂饲料喂养12周,制备非酒精性脂肪肝大鼠模型,连续给药4周后取材,HE染色,观察肝组织病理变化,比色法检测血清中ALT、AST、SOD、MDA的含量变化,RT-PCR和免疫组化法检测COX-...
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| 关 键 词： | 粗叶悬钩子总生物碱 非酒精性脂肪肝 抗氧化机制 |
Anti-oxidation of Total Alkaloids from Rubus Alceaefolius Poir on Nonalcoholic Fatty Liver |
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| ZHAO Jinyan,ZHENG Yuqing,ZHENG Haiyin,et al. Anti-oxidation of Total Alkaloids from Rubus Alceaefolius Poir on Nonalcoholic Fatty Liver[J]. Journal of Fujian College of Traditional Chinese Medicine, 2011, 0(5): 15-17 |
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| Authors: | ZHAO Jinyan ZHENG Yuqing ZHENG Haiyin et al |
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| Affiliation: | ZHAO Jinyan1,ZHENG Yuqing2,ZHENG Haiyin2,et al(1.Fujian Academy of Integrative Medicine,FUTCM,Fuzhou,Fujian 350108,China,2.College of Integrative Medicine,China) |
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| Abstract: | Objective To investigate the anti-oxydative effect of total alkaloids from Rubus Alceaefolius Poir(TARAP) on nonalcoholic fatty liver(NFL) in rat.Methods 30 SD rats were randomly divided into blank control group,model group and TARAP groups with different doses respectively.The rats were fed with high fat forage for 12 weeks to establish the model of NFL.After successive administration for 4 weeks,the pathological change of hepatic tissue was observed by HE stain,the content changes of serum ALT,AST,SOD and... |
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| Keywords: | total alkaloids from Rubus Alceaefolius Poir nonalcoholic fatty liver antioxidant mechanism |
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