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| 粗叶悬钩子总生物碱治疗大鼠非酒精性脂肪肝的实验研究 | |
| 引用本文： | 林玮,徐柯,郑海音,郑玉清,伍娟,赵锦燕,洪振丰.粗叶悬钩子总生物碱治疗大鼠非酒精性脂肪肝的实验研究[J].福建中医学院学报,2011,21(4):31-34. |
| 作者姓名： | 林玮 徐柯 郑海音 郑玉清 伍娟 赵锦燕 洪振丰 |
| 作者单位： | 1. 福建中医药大学实验动物中心,福建福州,350108 2. 福建中医药大学中西医结合学院,福建福州,350108 3. 福建中西医结合研究院,福建福州,350108 |
| 基金项目： | 福建省自然科学基金课题(2010J01191); 福建省医学创新课题(2009-CX-18); 福建省教育厅课题(JA09138) |
| 摘 要： | 探讨粗叶悬钩子总生物碱对非酒精性脂肪肝大鼠的作用. 方法SD大鼠60只随机分为空白对照组、模型组、多烯磷脂酰胆碱( PPC)对照组与粗叶悬钩子总生物碱(TARAP)低、中、高剂量组,以高脂饲料喂养12周制备实验性非酒精性脂肪肝大鼠模型.连续给药4周后取材.观察肝组织粗脂肪含量和血清TG、TC、LDL -C、HDL -C... |
| 关 键 词： | 粗叶悬钩子总生物碱 非酒精性脂肪肝 脂质代谢 TG TC LDL-C HDL-C |
Experimental Study about Total Alkaloids from Rubus alceaefolius Poir on Treatment of Nonalcoholic Fatty Liver Rat |
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| LIN Wei,XU Ke,ZHENG Haiyin,et al.Experimental Study about Total Alkaloids from Rubus alceaefolius Poir on Treatment of Nonalcoholic Fatty Liver Rat[J].Journal of Fujian College of Traditional Chinese Medicine,2011,21(4):31-34. | |
| Authors: | LIN Wei XU Ke ZHENG Haiyin |
| Institution: | LIN Wei1,XU Ke2,ZHENG Haiyin2,et al(1.Laboratory Animal Center,FUTCM,Fuzhou,Fujian 350108,China,2.College of Integrative Medicine,China) |
| Abstract: | Objective To study the role and mechanism of total alkaloids from Rubus alceaefolius Poir(TARAP) for the treatment of nonalcoholic fatty liver(NFL).Methods 60 SD rats were randomly divided into blank control group,model group,polyene phosphatidylcholine(PPC) group and TARAP groups with different doses respectively.The rats were fed with high fat forage for 12 weeks to establish the model of NFL.After successive administration for 4 weeks,the content changes of crude fat of hepatic tissue and serum TG,TC,LDL... |
| Keywords: | total alkaloids from Rubus alceaefolius Poir nonalcoholic fatty liver lipid metabolism TG TC LDL-C HDL-C |
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