| 川贝母止嗽颗粒的急性毒性测试 |
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| 引用本文： | 孙涛,彭成. 川贝母止嗽颗粒的急性毒性测试[J]. 成都中医药大学学报, 2011, 0(3): 60-61 |
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| 作者姓名： | 孙涛 彭成 |
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| 作者单位： | 成都中医药大学药学院,四川成都,610075 |
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| 基金项目： | 国家“十一五”科技支撑计划重点项目(编号:2009BAI84B04) |
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| 摘 要： | 目的：评价川贝母止嗽颗粒的急性毒性。方法：小鼠灌胃给予川贝母止嗽颗粒流浸膏,每日3次,连续观察14 d内小鼠的体重、饮食,毒性反应及死亡情况。结果：给药组和对照组小鼠在第1、7、14 d的体重并无差异（P〉0.05）;川贝母止嗽颗粒小鼠的最大耐受量（MTD）为187.53 g/kg（成人临床日用量的201倍）。结论：川贝母止嗽颗粒在临床常用剂量下是安全的。
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| 关 键 词： | 川贝母 咳嗽 急性毒性 最大耐受量 |
Study of Acute Toxicity of Bulbus Fritillariae Cirrhosae Cough Relieving Granule |
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| SUN Tao , PENG Cheng. Study of Acute Toxicity of Bulbus Fritillariae Cirrhosae Cough Relieving Granule[J]. Journal of Chengdu University of Traditional Chinese Medicine, 2011, 0(3): 60-61 |
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| Authors: | SUN Tao PENG Cheng |
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| Affiliation: | SUN Tao,PENG Cheng(Pharmacy College of Chengdu University of Chinese Traditional Medicine,Chengdu 610075,China) |
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| Abstract: | Objective: To evaluate the acute toxicity of Bulbus Fritillariae Cirrhosae cough relieving granule.Methods:The mice were intragastrically administered with fluid extract of Bulbus Fritillariae Cirrhosae cough relieving granule for 3 times per day,consecutively observing the body weight,diet,toxic reaction and death of mice for 14 days.Results:There was no significant difference between the body weight of mice in the group of fluid extract and control(P>0.05);the maximum tolerated dose(MTD) of Bulbus Fritill... |
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| Keywords: | Bulbus Fritillariae Cirrhosae cough acute toxicity MTD |
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