| 仙鹤草水提物急性毒性和遗传毒性实验研究 |
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| 引用本文： | 陆英,张洁.仙鹤草水提物急性毒性和遗传毒性实验研究[J].长春中医药大学学报,2011,0(5):709-711. |
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| 作者姓名： | 陆英 张洁 |
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| 作者单位： | 1. 海门市悦来医院,江苏海门,226131
2. 南通大学,江苏南通,226007 |
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| 摘 要： | 目的:对仙鹤草的安全性进行评价，以便为仙鹤草的综合利用提供依据。方法:运用急性毒性试验、小鼠骨髓微核实验对仙鹤草进行系统的安全性评价。结果:仙鹤草的半数致死剂量(LD50)＞80 g/kg，并且小鼠骨髓微核实验结果为阴性。结论:仙鹤草属无毒物质，本试验条件下无致染色体畸变作用。因此初步认为仙鹤草是一种比较安全的中药。
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| 关 键 词： | 仙鹤草 急性毒性 遗传毒性 大鼠 |
Experimental study on acute toxicity and genetic toxicity of Agrimoni a pilosa Ledeb |
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| LU Ying,ZHANG Jie.Experimental study on acute toxicity and genetic toxicity of Agrimoni a pilosa Ledeb[J].Journal of Changchun College of Traditional Chinese Medicine,2011,0(5):709-711. |
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| Authors: | LU Ying ZHANG Jie |
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| Institution: | LU Ying1,ZHANG Jie2(1.Yuelai Hospital of Haimen,Haimen,Jiangsu 226131,2.Nantong University,Nantong Jiangsu 226007) |
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| Abstract: | Agrimoni a pilosa Ledeb is a traditional Chinese herbal medicine,although it was listed as a food,the relative systematic toxicity and safety evaluation experiment was lacking.Methods:Systematic safety evaluation experiments were done using acute toxicity and genetic toxicity experiments including mice bone marrow micro-nuclear test.Results:LD50 was higher than 80 g/kg;no significant differences were observed in micronuclei rates.All toxicity tests were negative.Conclusion:It was found that Agrimoni a pilos... |
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| Keywords: | Agrimoni a pilosa Ledeb acute toxicity genetic toxicity |
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