中药敷脐防治儿童哮喘的临床观察

目的:观察中药喘敷灵敷脐对缓解期哮喘患儿血清IgE、嗜酸性粒细胞(EOS)、一氧化氮(NO)、一氧化氮合酶(NOS)浓度的影响,观察该方法对哮喘患儿最大呼气流速(PEF)及临床发作情况的影响,为更有效地防治该病探索新方法.方法:选取120例缓解期哮喘患儿,随机分为四组:全年敷组30例,在单纯三伏敷贴的基础上,每隔10天用凡士林调喘敷灵敷脐;三伏敷组30例,分别在三伏的第一天外敷姜汁调喘敷灵,共3次;西药组30例,吸入普米克气雾剂;空白组30例,用凡士林调安慰剂敷脐,方法同全年敷组,后三组共1年.四组患儿均于三伏敷贴前及敷后1年各测定血清IgE、EOS、NO、NOS浓度1次,并于2000年及2001年三伏敷贴期间,对缓解期哮喘患儿测定PEF,每个敷贴日测3次,取最大值为测定值.分别比较每组治疗前后上述指标的变化情况.结果:中药外敷在控制哮喘患儿临床症状,降低患儿血清IgE、EOS、NO、NOS浓度,改善肺功能,提高PEF值及机体免疫力等方面疗效接近西药组,并且全年敷较单纯三伏敷疗效更好(P＜0.05或0.01).结论:运用中药敷脐防治儿童哮喘,不仅能很好地控制患儿临床症状,改善各项生化指标和调节机体免疫状态,而且易于操作,经济实用.

Clinical observe of prevent and treat children asthma using drugs at the umbilical region

Objective: To investigate the regulation of Chuanfuling(CFL) on IgE, EOS, NO, NOS, PEF and effect of clinical attack in remission stage of children asthma. Methods: 120 patients were randomly divided into 4 groups. Sanfu group applied CFL on the first day in Sanfu separately. One year group applied CFL every 10 days except applied drugs in Sanfu days. Western Medicine group inhalated Pumike aerosol. Control group applied placebo. IgE, EOS, NO, NOS in blood of 4 groups were determined at before and after Sanfu days. At the same time, determined PEF in remission stage of children asthma in Sanfu days in 2000 and 2001. Results: The curative effects of Chinese herbs was approach to Western Medicine in controling clinical symptom, decrease blood IgE, EOS, NO, NOS, improving pulmonary function, increasing PEF and immunologic function. The one year group was better than Sanfu group(P <0.05 or P <0.01). Conclusion: Chinese herbs not only can control children's clinical symptom, improve biochemical criterion and regulate immunologic function, but also operate easily, is economical and practical in clinic.