盐酸贝尼地平治疗稳定型心绞痛的疗效观察

目的:观察盐酸贝尼地平对稳定型心绞痛患者的临床疗效。方法:80例稳定型心绞痛患者随机分为治疗组和对照组。治疗组给予盐酸贝尼地平片(4mg,bidpo),对照组给予硝苯地平控释片(30mg,qdpo),4周后观察心绞痛改善情况、消心痛使用量、心肌缺血程度等,监测不良反应事件,同时进行安全评价。结果:治疗组心绞痛症状明显改善,总有效率达90%,与对照组(总有效率65%)比较有显著性差异(P<0.05);消心痛使用量明显下降,总有效率达85%,与对照组(总有效率50%)比有显著性差异(P<0.01)。在运动试验中,治疗组总运动时间、运动至ST段下降至1mm所需时间、运动至心绞痛出现时间均明显延长,与对照组比亦有显著性差异(P分别<0.05、0.01、0.01);与治疗前相比有显著性差异(P分别<0.01、0.05、0.01)。最大运动当量也有增加,与对照组相比亦有显著性差异(P<0.05),与疗前比有显著性差异(P<0.01)。最大ST段下降幅度与疗前比有显著性差异(P<0.05),与对照组比无显著性差异(P>0.05);对照组运动至心绞痛出现时间明显延长,与疗前比有显著性差异(P<0.05),其余四项指标均无明显改善,与疗前比均无显著性差异(P均>0.05)。治疗组用药后不良反应事件总发生率12.5%,与对照组相比无显著性差异(P>0.05)。结论:与硝苯地平比,盐酸贝尼地平治疗稳定型心绞痛有更好的疗效及安全性。

The eff icacy of benidipine hydrochloride in the use of stable angina pectoris

Objective:To observe the efficacy of benidipine hydrochloride in the use of stable angina pectoris.Methods:80 patients from Feb 2005 to Mar 2007 were divided randomly into two groups.40 cases in treated group using benidipine hydrochloride and the control group were treated with nifidipine(slow released),then measure the effects.Results:As compared with the control,the symptom was obviously improved(90% vs 65% P<0.05),the use of isosorbide dinitrate was decreased(85% vs 50% P<0.01).In the exercise tolerance test,the totle exercise time,time to onset of angina and to 1 mm ST segment depression was obviously prolonged(P<0.05 0.01and 0.01).The maximal matebolic equivalent(METmax) improved signifi cantly(P<0.01).For the treat group only,there also were improved signifi cantly by the medicine treatment for the upper four index(P<0.01、0.05、0.01、0.01);The maximal ST depression were improved signifi cantly(P<0.05);while there was no obvious improvement to control group(P>0.05).In the control group,time to onset of angina was prolonged after treatment(P <0.05),the other index has no change.Also there were no change about the liver function,kidney function,fasting blood glucose and cholesterol when the medicine used or not(P>0.05).The total side effect incidence was no difference(P>0.05).Conclusion:The function of the benidipine hydrochloride was very obvious and safe on treating of stable angina pectoris.