瘦素与非酒精性脂肪性肝病的关系

啮齿类动物胰岛分离的应用广泛 ,其方法也早已建立 ,但影响胰岛分离的因素较多 ,使获得足量、纯净、存活和功能良好的胰岛常较困难 ,且胰岛分离的稳定性和一致性亦难令人满意。因此 ,针对分离技术、纯化方法、分离剂、消化酶及消化条件等诸方面进行了广泛的改进 ,胰岛的收获量、纯度及活力等均有显著的提高。

Relationship between leptin and nonalcoholic fatty liver disease

Leptin is an adipocytokine produced primarily in white adipose tissue. It belongs to pro-teohormone and plays biological effect by binding with leptin receptor. It is found that leptin regulates the me-tabolism of body and controlls the fatty mass. Recently studies have indicated that it is closely related to non-alcoholic fatty liver disease (NAFLD), but the results varied in different researches. Some found that there was no significant relation between higher level of leptin and NAFLD. On the contrary, others considered that leptin had indenpendent and very important role in the pathogenesis of NAFLD. The weakeness of leptin's an-tilipotoxicity and leptin resistance are considered as very important links in the pathogenesis of NAFLD.