| 114对反复流产夫妇的染色体分析 |
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| 引用本文： | 周波,唐艳平,杨真荣,陈燕. 114对反复流产夫妇的染色体分析[J]. 中国妇幼保健, 2007, 22(1): 126-128 |
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| 作者姓名： | 周波 唐艳平 杨真荣 陈燕 |
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| 作者单位： | 1. 温州医学院生命科学院生物系,浙江,温州,325035
2. 华中科技大学同济医学院生物系 |
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| 摘 要： | 目的:分析反复流产夫妇的异常核型发生率、形成原因及其染色体分析的临床价值。方法:对114对反复流产夫妇行外周血染色体分析。结果:检出异常染色体核型13例,占受检夫妇人数的5·7%,异常核型中,平衡易位最多,占异常总数的76·92%,其中相互易位10例,罗伯逊易位3例;其次为倒位,为6号、9号以及Y染色体的臂间倒位。结论:对于不明原因的反复流产夫妇,染色体分析必须作为常规的检测方法。
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| 关 键 词： | 反复流产 染色体异常 倒位 |
| 文章编号： | 1001-4411（2007）01-0126-03 |
| 修稿时间： | 2005-07-08 |
Chromosome analysis of 114 couples with recurrent spontaneous abortion |
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| ZHOU Bo , TANG Yan -Ping, YANG Zhen -Rong,et al.. Chromosome analysis of 114 couples with recurrent spontaneous abortion[J]. Maternal and Child Health Care of China, 2007, 22(1): 126-128 |
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| Authors: | ZHOU Bo TANG Yan -Ping YANG Zhen -Rong et al. |
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| Affiliation: | Department of Biology, College of Life Sciences, Wenzhou Medical College, Wenzhou 325035, Zhejiang , China |
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| Abstract: | Objective:To analyze the incidence and reasons of abnormal karyotypes and clinical value of chromosome analysis in recurrent spontaneous abortion (RSA).Methods:Chromosome analysis was performed on 114 couples with RSA.Results:13 cases of abnormal karyotypes were detected (5.7%).Balanced translocations had the most abnormalities (76.92%), including 10 balanced reciprocal translocations and 3 balanced Robertsonian translocations. The other types of abnormal karyotpyes were balanced pericentric inversions, affected chromosome 6, 9 and Y.Conclusion:Chromosomal analysis should be carried out routinely in every couple with unexplained failure of reproduction. |
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| Keywords: | Recurrent spontaneous abortion Chromosome aberrations Inversion |
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