p27在胃癌演化系列组织中的表达及其意义

目的　探讨p2 7蛋白表达在胃癌发生和发展中的作用以及与肿瘤生物学行为的关系。方法　应用免疫组织化学方法 ,检测p2 7蛋白在浅表性胃炎、萎缩性胃炎、肠化生、异型增生和胃癌组织中的表达 ,分析p2 7在不同病变组织中的表达状况以及与胃癌临床病理参数的关系。结果　p2 7在胃癌中的表达强度低于其他组织 (P <0 .0 1) ;p2 7表达与胃癌浸润深度、淋巴结转移、远处转移、TNM分期等临床病理参数相关 (P <0 .0 1) ,在有浆膜侵犯、淋巴结或远处转移、TNM分期晚的胃癌中p2 7表达强度显著下降。结论　p2 7表达异常是胃癌发生和发展的一个重要分子机制。分析p2 7蛋白表达状况有助于胃癌的早期诊断及恶性程度评估。

Significance of p27 expression in gastric carcinoma and precancerous lesion

Objective To evaluate the role of p27 protein in genesis and progre ssion of gastric carcinoma, and the relationship between expression of p27 and b iological behavior of gastric carcinoma. Methods The immunohis tochemical method was used to detect the expression of p27 in superficial gastri tis, atrophic gastritis, intestinal metaplasia, dysplasia and gastric carcinoma specimen. The level of p27 protein in tissues with different types of lesion and its correlation with clinicopathological parameters of gastric carcinoma were a nalyzed. Results The expression level of p27 in gastric carci noma tissues was significantly lower than that of other tissues (P<0 . 01), which was correlated with depth of invasion, lymph node metastasis, distant metastasis and TNM stage of gastric carcinoma (P<0.01). The express i on of p27 decreased significantly in gastric carcinoma with serosa infiltration, lymph node metastasis, distant metastasis, and late TNM staging. Conc lusions Aberrant expression of p27 is an important molecular mechanism involved in the pathogenesis and progression of gastric carcinoma, which is ass ociated with aggressive characteristics of gastric carcinoma. The assessment of p27 expression may prove valuable in the early diagnosis and judgment of maligna nt degree of gastric carcinoma.