C-反应蛋白含量与冠状动脉狭窄程度关系的研究

目的:探讨C-反应蛋白(C-reactive protein,CRP)含量与冠状动脉粥样硬化病变程度的关系。方法:对506例冠脉造影患者(其中男性376例,女性130例)的冠状动脉造影结果,采用Gensini评分系统对冠状动脉血管病变程度进行定量评分,得出Gensini积分。CRP采用微粒子增强透射免疫试验检测。统计分析CRP含量与冠状动脉粥样硬化狭窄程度的关系。结果:由低至高hsCRP四分位分组后,患者的血脂、血糖以及Gensini积分在不同hsCRP组间差异有显著性。年龄、血糖和hsCRP与Gensini积分呈显著正相关,hsCRP是Gensini积分的独立影响因子。结论:血中hsCRP浓度的含量与冠状动脉病变的程度呈正相关,对冠心病的病变程度具有预测价值。

Relationship between C-reactive protein level and angiographical characteristics of coronary atherosclerosis

Objective: To explore the relationship between C-reactive protein and coronary atherosclerosis.Methods: The study concluded 506 consecutive patients(376 males and 130 females) who underwent coronary angiography for suspected or known coronary atherosclerosis.The severity of coronary atherosclerosis was defined by the Gensini's score system.The C-reactive protein level was measured by particle enhanced immunoturbidimetric assay.Results: When hsCRP level was examined as a categorical variable classified by quartile values,blood glucose,lipid and Gensini's score differed among the groups.Gensini's score was significantly associated with age,blood glucose and the level of hsCRP respectively.hsCRP was independently associated with the Gensini's score.Conclusion: the level of plasma hsCRP was significantly associated with the severity of coronary atherosclerosis and independent from other traditional cardiovascular risk factors.