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C-反应蛋白含量与冠状动脉狭窄程度关系的研究
引用本文:丁亚媛,杨志健,贾恩志,朱铁兵,王连生,陈波,曹克将,马文珠,DING Ya-yuan,YANG Zhi-jian,JIA En-zhi,ZHU Tie-bing,WANG Lian-Sheng,CHEN BO,CAO Ke-jiang,MA Wen-zhu. C-反应蛋白含量与冠状动脉狭窄程度关系的研究[J]. 南京医科大学学报(自然科学版), 2006, 26(6): 441-444
作者姓名:丁亚媛  杨志健  贾恩志  朱铁兵  王连生  陈波  曹克将  马文珠  DING Ya-yuan  YANG Zhi-jian  JIA En-zhi  ZHU Tie-bing  WANG Lian-Sheng  CHEN BO  CAO Ke-jiang  MA Wen-zhu
作者单位:南京医科大学第一附属医院心内科,江苏,南京,210029;南京医科大学第一附属医院心内科,江苏,南京,210029;南京医科大学第一附属医院心内科,江苏,南京,210029;南京医科大学第一附属医院心内科,江苏,南京,210029;南京医科大学第一附属医院心内科,江苏,南京,210029;南京医科大学第一附属医院心内科,江苏,南京,210029;南京医科大学第一附属医院心内科,江苏,南京,210029;南京医科大学第一附属医院心内科,江苏,南京,210029
摘    要:目的:探讨C-反应蛋白(C-reactive protein,CRP)含量与冠状动脉粥样硬化病变程度的关系。方法:对506例冠脉造影患者(其中男性376例,女性130例)的冠状动脉造影结果,采用Gensini评分系统对冠状动脉血管病变程度进行定量评分,得出Gensini积分。CRP采用微粒子增强透射免疫试验检测。统计分析CRP含量与冠状动脉粥样硬化狭窄程度的关系。结果:由低至高hsCRP四分位分组后,患者的血脂、血糖以及Gensini积分在不同hsCRP组间差异有显著性。年龄、血糖和hsCRP与Gensini积分呈显著正相关,hsCRP是Gensini积分的独立影响因子。结论:血中hsCRP浓度的含量与冠状动脉病变的程度呈正相关,对冠心病的病变程度具有预测价值。

关 键 词:C反应蛋白  冠状动脉病变  Gensini积分
文章编号:1007-4368(2006)06-0441-04
收稿时间:2005-11-08
修稿时间:2005-11-08

Relationship between C-reactive protein level and angiographical characteristics of coronary atherosclerosis
DING Ya-yuan,YANG Zhi-jian,JIA En-zhi,ZHU Tie-bing,WANG Lian-Sheng,CHEN BO,CAO Ke-jiang,MA Wen-zhu. Relationship between C-reactive protein level and angiographical characteristics of coronary atherosclerosis[J]. Acta Universitatis Medicinalis Nanjing, 2006, 26(6): 441-444
Authors:DING Ya-yuan  YANG Zhi-jian  JIA En-zhi  ZHU Tie-bing  WANG Lian-Sheng  CHEN BO  CAO Ke-jiang  MA Wen-zhu
Affiliation:Department of Cardiovascular Medicine, the First Affiliated Hospital of NJMU,Nanjing 210029, China
Abstract:Objective: To explore the relationship between C-reactive protein and coronary atherosclerosis.Methods: The study concluded 506 consecutive patients(376 males and 130 females) who underwent coronary angiography for suspected or known coronary atherosclerosis.The severity of coronary atherosclerosis was defined by the Gensini's score system.The C-reactive protein level was measured by particle enhanced immunoturbidimetric assay.Results: When hsCRP level was examined as a categorical variable classified by quartile values,blood glucose,lipid and Gensini's score differed among the groups.Gensini's score was significantly associated with age,blood glucose and the level of hsCRP respectively.hsCRP was independently associated with the Gensini's score.Conclusion: the level of plasma hsCRP was significantly associated with the severity of coronary atherosclerosis and independent from other traditional cardiovascular risk factors.
Keywords:C-reactive protein  coronary atherosclerosis  Gensini's score
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