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| 肝组织庚型肝病毒抗原的表达状况及临床意义 | |
| 引用本文： | 杨志国,许家璋,隋云华,何长伦,乐美兆,高蕾,周育森,陈万荣.肝组织庚型肝病毒抗原的表达状况及临床意义[J].江苏医药,2000,26(6):425-427. |
| 作者姓名： | 杨志国 许家璋 隋云华 何长伦 乐美兆 高蕾 周育森 陈万荣 |
| 作者单位： | 1. 210002,南京,解放军第81医院肝病研究所 2. 210002,南京,解放军第81医院病理科 3. 解放军军事医学科学院五所 |
| 基金项目： | 全军“九五”(B类 )课题!( 96D0 2 9) |
| 摘 要： | 目的 研究血清庚型肝炎病毒核糖核酸（ＨＧＶＲＮＡ）阳性或阴性肝病肝组织中的ＨＧＶ抗原（ＨＧＶＡｇ）的表达状况及其临床意义。方法 应用抗ＨＧＶ非结构５区（ＮＳ５）单克隆抗体（ＭｃＡｂ），以免疫组织化学ＢＡ法检测肝细胞中ＨＧＶＮＳ５抗原。结果ＨＧＶＡｇ阳性染色为棕黄色，呈红小颗粒状位于肝细胞胞浆，肝组织中阳性肝细胞呈散在分布；在血清ＨＧＶＲＮＡ阳性和阴性肝组织中ＨＧＶＡｇ的检出率分别为６３．６４％（ |
| 关 键 词： | 庚型肝炎病毒 免疫组织化学 抗原 |
Expression of hepatitis G virus NS5 antigen in liver tissue and its clinical significance |
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| YANG Zhiguo,XU Jiazhang,SUI Yunhua et al.Expression of hepatitis G virus NS5 antigen in liver tissue and its clinical significance[J].Jiangsu Medical Journal,2000,26(6):425-427. | |
| Authors: | YANG Zhiguo XU Jiazhang SUI Yunhua et al |
| Institution: | YANG Zhiguo,XU Jiazhang,SUI Yunhua et al.The Institute of the 81st Hospital of PLA,Nanjing 210002 |
| Abstract: | Objective To investigate the expression of hepatitis G virus(HGV) NS 5 antigen in liver tissue from patients with HGVRNA(RT PCR) seropositive or seronegative.Methods Liver specimens from patients with hepatitis were detected by immunohistochemical method with monoclonal antibody to HGV NS 5.Results The HGVAg positive staining was brown in color.HGVAg was presented as granule in cytoplasm of liver cell.The HGVAg positive hepatocytes were found to spread sporadically.The percentages of HGVAg positive staining were 63 64%(7/11) and 5 62%(5/89)from patients with HGVRNA seropositive and seronegative respectively.Conclusion HGV is hepatotropic virus.The expression of hepatic HGVAg had distinct relationship with the level of serum HGVRNA. |
| Keywords: | Hepatitis G virus Immunohistochemistry |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |