Mechanisms of modulation of GABA-induced currents in isolated cerebellar cells by tacrine |
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| Authors: | S N Kolbaev I N Sharonova V S Vorob'ev V G Skrebitskii |
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| Institution: | (1) Brain Research Institute, Russian Academy of Medical Sciences, Moscow |
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| Abstract: | Tacrine, when applied by the concentration clamp technique to isolated Purkinje cells from rat cerebellum, dose-dependently
reduced the amplitude of GABA-activated chloride currents recorded by the patch clamp technique. Half-maximal inhibition (IC50) of currents activated by 2 μM GABA was observed at a tacrine concentration of 107 μM. Tacrine produced a right shift of
the dose-response curves for GABA-induced currents without affecting their peak amplitudes. It is suggested that suppression
of GABA-induced currents caused by tacrine can not be attributed to its interaction with the benzodiazepine site of the GABAA receptor.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 5, pp. 539–542, May, 1999 |
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| Keywords: | tacrine GABA A -receptors cerebellum Alzheimer disease voltage clamp |
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