| Abstract: | Adhesion of guinea pig bone marrow and spleen cells to stromal mechanocytes of medullary, splenic, and thymic origin, to peritoneal exudate fibroblasts, and also to macrophages was studied in monolayer cultures. Primary cultures and subcultures of fibroblasts were able to bind hematopoietic cells and lymphocytes, and this property was independent of the origin of the mechanocytes. Hematopoietic cells were much less adherent to macrophages. Adhesion of cells to mechanocytes is determined by the number of adhesion sites present on the surface of the fibroblasts. There are significantly more of these sites for adhesion of myeloid cells on the surface of stromal mechanocytes than for adhesion of lymphocytes.Laboratory of Immunomorphology, N. F. Gamaleya Institute of Epidemiology and Microbiology, Academy of Medical Sciences of the USSR, Moscow. Department of Medical Biophysics, Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR V. A. Vershilov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 88, No. 12, pp. 703–704, December, 1979. |
