| 接触二硫化碳大鼠铜水平与血浆LCAT活性的变化及关系的研究 |
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| 引用本文： | 黄陈平 胡迪生. 接触二硫化碳大鼠铜水平与血浆LCAT活性的变化及关系的研究[J]. 中国职业医学, 1996, 23(5): 4-5 |
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| 作者姓名： | 黄陈平 胡迪生 |
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| 作者单位： | 温州医学院卫生学教研室(黄陈平)，浙江医科大学卫生学教研室(胡迪生) |
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| 摘 要： | ＳＤ大鼠分别用５ｍｇ／ｍ３和５０ｍｇ／ｍ３ＣＳ２吸入染毒６个月。结果表明：５０ｍｇ／ｍ３ＣＳ２接触组肝铜含量显著减少（Ｐ＜０．０５），血浆ＬＣＡＴ活性显著抑制（Ｐ＜０．０１）。肝铜含量与血浆ＬＣＡＴ活性呈正线性相关（Ｐ＜０．０１）。实验结果提示：ＣＳ２能引起铜代谢紊乱，降低体内铜水平；血浆ＬＣＡＴ是一种铜酶；ＣＳ２可通过干扰铜代谢，从而抑制ＬＣＡＴ活性，引起脂质代谢紊乱。
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| 关 键 词： | 二硫化碳 铜 卵磷脂─胆固醇酰基转移酶 |
Effects of carbon disulfide on the copper metabolism and plasma lecithin cholesterol acyltransferase activity in exposed rats |
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| Huang Chenping,et al. Effects of carbon disulfide on the copper metabolism and plasma lecithin cholesterol acyltransferase activity in exposed rats[J]. China Occupational Medicine, 1996, 23(5): 4-5 |
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| Authors: | Huang Chenping et al |
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| Abstract: | prague Dawley rats had inhaled CS 2 vapours 5 hours a day,6 days a week for six months The CS 2 concentrations were 5mg/m 3 and 50mg/m 3 respectively The results showed that the level of liver copper was significantly decreased( P <0 05) and the plasma LCAT activity was significantly inhibited( P <0 01) in the group having exposed to 50mg/m 3 CS 2 vapour for six months A significant positive linear correlation existed between the plasma LCAT activities and liver copper values( P <0 01) The conclusions might be as follow:Exposure to CS 2 could result in disturbances of copper metabolism LCAT,as a kind of copper metalloenzymes,could be inhibited by CS 2 through interfering copper metabolism and result in the disturbances of lipid metabolism |
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| Keywords: | carbon disulfide copper lecithin cholesterol acyltrasferase |
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