| 尿中粘康酸HPLC方法检测在苯生物监测中的应用研究 |
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| 引用本文： | 杨爱初,曾年华.尿中粘康酸HPLC方法检测在苯生物监测中的应用研究[J].中国职业医学,1996,23(2):6-8. |
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| 作者姓名： | 杨爱初 曾年华 |
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| 作者单位： | 广东省职业病防治院，广州军区军事医学研究所 |
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| 摘 要： | 尿粘康酸是苯代谢产物中的一个极小分支，由于其在体内极低的本底值而受到重视。本研究采用强阴离子交换树脂预处理尿样，用ＨＰＬＣ—ＵＶ检测苯作业工人班前班末尿粘康酸浓度，并与尿酚及个体苯加权平均浓度进行相关分析。研究发现，苯作业工人尿粘康酸与尿酚、苯加权平均浓度三者之间良好相关，尿粘康酸比尿酚具备更好的敏感性与特异性，并能在个体苯加权平均浓度约３．８ｍｇ／ｍ￣３水平区分个体苯接触，尿粘康酸在苯生物监测中前景广阔。
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| 关 键 词： | 尿粘康酸，尿酚，个体苯加权平均浓度 |
Rolc of urinary TTMA byHPLC detection in benzcne biomonittiring |
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| Yang Aichli,et al..Rolc of urinary TTMA byHPLC detection in benzcne biomonittiring[J].China Occupational Medicine,1996,23(2):6-8. |
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| Authors: | Yang Aichli |
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| Abstract: | rinary trans.trans-muconic acH(TTMA),aminor benzene metabolite,has been used as ahomarker Of benzene exposure because of its little in -terference;Using the method of strong anion rcsinsabsorption and HPLC-LV detection,it was foundthat a rather good correlations was existed among uri-nary TTMA,urinary phenol,and individual benzeneTWA, and that TTMA appeared to have better sensi-tivity and specificity than that of phenol.It seemedthat TTMA would be a promisink biomarker of ben-zene exposure,capable to differentiate individual benzene exposure level at 3. 8mg/m3 benzene TWA. |
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| Keywords: | TTMA urinary phenol individualbenzene TWA |
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