Isolation of amantadine-resistant influenza a viruses (H3N2) from patients following administration of amantadine in Japan |
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| Authors: | Iwahashi J Tsuji K Ishibashi T Kajiwara J Imamura Y Mori R Hara K Kashiwagi T Ohtsu Y Hamada N Maeda H Toyoda M Toyoda T |
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| Affiliation: | Department of Virology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan. |
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| Abstract: | In Japan, the use of amantadine for treatment of influenza A virus infection was not accepted until November 1998, although it was widely used for treatment of Parkinsonism. Since then, we have monitored the emergence of amantadine-resistant viruses and isolated two viruses from patients on long-term treatment with amantadine. |
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