血管免疫母细胞性淋巴结病临床病理及免疫组化研究

目的：研究血管免疫母细胞性淋巴结病（ＡＩＬＤ）的临床、病理和免疫组化特点，为ＡＩＬＤ的诊断提供依据。方法：分析１１例ＡＩＬＤ临床病理特点，并用７种抗体对其中１０例作免疫组化标记。结果：本组ＡＩＬＤ患者以全身浅表淋巴结肿大、发热、高丙球蛋白血症等为主要临床特点，部分病人血乳酸脱氢酶增高。主要组织学改变为：淋巴结结构破坏，免疫母细胞为主的淋巴细胞系列性增生和分支小血管显著增生。免疫组化研究表明，多数患者增生的淋巴细胞为Ｔ细胞（其中５例为辅助性Ｔ淋巴细胞，３例为抑制性Ｔ淋巴细胞），少数患者Ｂ淋巴细胞系列增生。结论：本组多数病例系列增生淋巴细胞为Ｔ细胞系列；本病确诊依赖病理组织学检查，其预后不良。

A Clinicopathological and Immunohistochemical Study of Angioimmunoblastic Lymphadenopathy

To study clinical, pathological and immunohistological features of angioimmunoblastic lymphadenopathy (AILD) for the benifit of its clinical diagnosis. METHODS:Pathological features of 11 AILD cases were analysed and 10 of which were labelled immunohistochomically. RESULTS:The clinical features of patients studied are characterized by enlargement of superficial lymph nodes, fever, hypergammaglobucinemia. A high level of lactic dehydrogenase in blood was found in part of the patients. The main pathological changes includes damages of the nodal sturcture, predominance of obundant small vessels and a series of lymphocytes with predominance of immunoblasts. Immunohistochamical study of 10 cases showed that CD45 RO were positive in 8 cases, CD20 in 2 cases. the proliferted lymphocytes are defined as T cells in most of our patients. CONCLOSIONS:The proliferated lymphocytes are T cells in most patients. The confirmed diagnosis of the disease should depend on pathologicalexamination. Prognosis of the disease is poor.