Association analysis of COMT polymorphisms and schizophrenia in a Chinese Han population: a case-control study. |
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Authors: | Rui Yu Xian-Ning Zhang Xiao-Xiao Huang Shi-Ping Ding Ji-Cheng Li |
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Affiliation: | Department of Biochemistry and Genetics, and Department of Cell Biology, Institute of Cell Biology, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China. |
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Abstract: | Schizophrenia is a common disease with complex mode of inheritance; great efforts have been made to identify the susceptible genes. Catechol-O-methyltransferase (COMT) gene has long been considered as a candidate gene mainly because of two reasons: First, it encodes a key dopamine catabolic enzyme. Second, it maps to the velocardiofacial syndrome (VCFS) region of chromosome 22q11, which is associated with schizophrenia predisposition. Numerous case-control and family-based studies have been conducted, majority of them focused on a functional Val/Met polymorphism (rs4680). Unfortunately, these studies have produced conflicting results. In a previous report, Shifman et al. found a three-marker haplotype (rs737865-rs4680-rs165599) that showed significant association with schizophrenia. In this study, we try to replicate their findings in Chinese Han population and failed to find any associations. |
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