Serum antibodies to LDH-C4 |
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Authors: | J Shelton E Goldberg |
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Affiliation: | Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60201, U.S.A. |
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Abstract: | Human sera from the WHO Reference Bank were tested by a liquid phase radioimmunoassay for antibodies to the sperm-specific form of lactate dehydrogenase (LDH-C4; LDH-X). Modestly elevated levels of antibodies were detected in about 10% of infertile males and females and in about 20% of vasectomized males, as well as in a few cases in other categories. The occurrence of this anti-LDH-C4 activity was without overt correlation with other anti-sperm antibody assays. The primary advantage of the radioimmunometric assay is its absolute specificity for a sperm antigen. These findings lend support to contraceptive vaccine development based on LDH-C4 antigenicity. |
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Keywords: | antibodies radioimmunoassay sperm antigens |
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