Five-year postsurgical monitoring of serum p53 antibody for locally advanced esophageal squamous cell carcinoma |
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Authors: | Ryosuke Kochi Satoshi Yajima Tatsuki Nanami Takashi Suzuki Yoko Oshima Natsuki Tokura Jun Takatsuka Kimihiko Funahashi Naobumi Tochigi Hideaki Shimada |
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Affiliation: | 1.Department of Surgery,Toho University School of Medicine,Tokyo,Japan;2.Department of Surgery,Sagamihara Chuo Hospital,Sagamihara,Japan;3.Department of Surgical Pathology,Toho University School of Medicine,Tokyo,Japan;4.Department of Clinical Oncology,Toho University Graduate School of Medicine,Tokyo,Japan |
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Abstract: | Serum p53 antibody (s-p53-Ab) titers were postoperatively monitored for over 5 years in a 67-year-old man with locally advanced esophageal squamous cell carcinoma. The tumor stage was classified as clinical stage II (cT3N0M0). Serum SCC antigen (s-SCC-Ag; 6.2 ng/mL) and s-p53-Ab (3.83 U/mL) were noted to be positive before surgery. Radical esophagectomy with three-field lymph node dissection was performed without neoadjuvant therapy. Pathological findings of the surgically resected specimens revealed a stage II tumor (pT3N0M0). Postoperatively, the patients did not receive any adjuvant therapy. Although the s-SCC-Ag was found to be negative at 2 months postoperatively, s-SCC-Ag was found to be six times positive despite no signs of recurrence. The s-p53-Ab titers constantly decreased to less than the cutoff value at 6 months postoperatively and continuously decreased over 5 years postoperatively. Finally, s-p53-Ab titers became less than the detection limit value at 60 months postoperatively. No recurrence was observed throughout the postoperative course. This case report is the first to describe the five-year monitoring of postoperative changes in s-p53-Ab titers in a patient with locally advanced esophageal squamous cell carcinoma without recurrence. s-p53-Ab titers seemed to be more useful than s-SCC-Ag for disease monitoring in this case. |
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