乳腺癌超声声像图表现与血清癌胚抗原、糖类抗原125、糖类抗原50表达的相关性

目的  分析乳腺癌超声声像图表现与血清癌胚抗原(CEA)、糖类抗原(CA)125、CA50表达的相关性。方法  回顾分析2020年6月~2022年9月于医院收治的100例疑似乳腺癌患者的病历资料，所有病例均接受超声检查，根据病灶病理检查结果分为恶性组(n=52)、良性组(n=48)，分析恶性组患者的超声声像图特征分布情况，化学发光免疫法检测患者血清CEA、CA125、CA50水平，比较超声声像图不同特征下乳腺癌患者的血清CEA、CA125、CA50水平变化并分析其相关性，比较恶性组、良性组患者血清CEA、CA125、CA50水平并分析其对乳腺癌的诊断价值。结果  恶性组超声声像图中表现出肿块≥2 cm、形态不规则、边缘毛刺征、纵横比 > 1、内部低/混合回声、后方回声衰减、微小钙化、病灶内富血供患者占比均高于良性组(P < 0.05)。超声声像图中肿块大小(≥2 cm vs < 2 cm)、纵横比(≤1 vs > 1)、内部回声(低/混合回声vs高/等回声)、后方回声(衰减vs无衰减)、微小钙化(有vs无)、病灶内血流分布(富血供vs乏血供)患者的血清CEA、CA125、CA50水平的差异有统计学意义(P < 0.05)，不规则形态乳腺癌患者血清CEA、CA50水平均高于规则形态乳腺癌患者(P < 0.05)，边缘毛刺征乳腺癌患者血清CA125、CA50水平均高于边缘无毛刺征乳腺癌患者(P < 0.05)。血清CEA、CA125、CA50水平与超声声像图特征中的纵横比 > 1、微小钙化、病灶内富血供呈正相关关系(r_{纵横比 > 1}=0.415、0.341、0.424，r_微小钙化=0.374、0.394、0.311；r_{病灶内富血供}=0.419、0.533、0.461，P < 0.05)。恶性组血清CEA、CA125、CA50水平分别为9.36±2.16 ng/mL、46.84±7.66 U/mL、42.61±6.48 μg/L，均高于良性组的6.9±2.04 ng/mL、38.73±8.82 U/mL、36.70±6.87 μg/L(P < 0.05)。血清CEA、CA125、CA50及其联合检测时的AUC分别为0.845、0.760、0.721、0.910，三项指标联合检测的AUC均高于其单独检测(Z_CEA/联合=2.109，P=0.035；Z_CA125/联合=3.232，P=0.001；Z_CA50/联合=3.821，P < 0.001)。结论  血清CEA、CA125、CA50水平与乳腺癌超声声像图特征中的肿块大小、微小钙化、病灶内富血供关系密切，其联合检测具有乳腺癌辅助诊断价值。

Correlation between ultrasonic image manifestations of breast cancer and serum carcinoembryonic antigen,carbohydrate antigen 125, carbohydrate antigen 50

Objective To analyze the correlation between ultrasonic image manifestations of breast cancer and serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125, CA50. Methods A retrospective analysis was performed on the case data of 100 patients with suspected breast cancer admitted to the hospital from June 2020 to September 2022. All patients underwent ultrasound examination. According to the results of pathological examination, they were divided into malignant group (n=52) and benign group (n=48). The characteristics of ultrasonic images in malignant group were analyzed. The levels of serum CEA, CA125 and CA50 were detected by chemiluminescence immunoassay. The changes of CEA, CA125 and CA50 in patients with different ultrasonic image characteristics were compared, and their correlation was analyzed. The levels of serum CEA, CA125 and CA50 in malignant group and benign group were compared, and their diagnostic value for breast cancer was analyzed. Results The proportions of cases with tumor ≥2 cm, irregular morphology, marginal spiculation, aspect ratio > 1, internal low/mixed echo, posterior echo attenuation, micro-calcification and abundant blood supply of lesions in malignant group were higher than those in benign group (P < 0.05). There were significant differences in levels of serum CEA, CA125 and CA50 among patients with different ultrasonic image characteristics [tumor size (≥2 cm vs < 2 cm), aspect ratio (≤1 vs > 1), internal echo (low/mixed echo vs high/equal echo), posterior echo (attenuation vs non-attenuation), micro-calcification (yes vs no), blood flow distribution (abundant blood supply vs lack of blood supply] (P < 0.05). The levels of serum CEA and CA50 in patients with irregular morphology of breast cancer were higher than those with regular morphology (P < 0.05). The levels of serum CA125 and CA50 in patients with marginal spiculation were higher than those without marginal spiculation (P < 0.05). The levels of serum CEA, CA125 and CA50 were positively correlated with aspect ratio > 1, micro-calcification and abundant blood supply of lesions (raspect ratio > 1=0.415, 0.341, 0.424; rmicro-calcification=0.374, 0.394, 0.311; rabundant blood supply of lesions=0.419, 0.533, 0.461, P < 0.05). The levels of serum CEA, CA125 and CA50 in malignant group were 9.36±2.16 ng/mL, 46.84±7.66 U/mL and 42.61±6.48 μg/L, higher than those in benign group (6.9±2.04 ng/mL, 38.73±8.82 U/mL, 36.70±6.87 μg/L, P < 0.05). AUC values of serum CEA, CA125, CA50 and combined detection were 0.845, 0.760, 0.721 and 0.910, respectively. AUC of combined detection was greater than that of single index (ZCEA/combination=2.109, P=0.035; ZCA125/combination=3.232, P=0.001; ZCA50/combination=3.821, P < 0.001). Conclusion The serum CEA, CA125 and CA50 are closely related to ultrasonic image characteristics of breast cancer (tumor size, micro- calcification, abundant blood supply of lesions), and their combined detection has auxiliary diagnosis value for breast cancer.