| 盐酸文拉法辛缓释片的初步研究 |
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| 引用本文： | 梁炜,周建平,虞阳.盐酸文拉法辛缓释片的初步研究[J].药学进展,2006,30(6):274-277. |
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| 作者姓名： | 梁炜 周建平 虞阳 |
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| 作者单位： | 中国药科大学药剂学教研室,江苏,南京,210009 |
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| 摘 要： | 目的：制备盐酸文拉法辛缓释片并考察其体外释放特性。方法：利用正交设计优化处方，建立释放度测定方法，根据不同时间累积释放度考察药物的释放情况，并采用不同方程拟合释放曲线。结果：用55％ HPMC K100M制得缓释片，其释放曲线可用一级方程动力学拟合。结论：用55％ HPMC K100M制备的盐酸文拉法辛缓释片具有良好的释药效果。
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| 关 键 词： | 盐酸文拉法辛 缓释片 羟丙基甲基纤维素 释药研究 |
| 文章编号： | 1001-5094（2006）04-0274-04 |
| 修稿时间： | 2006-02-21 |
Preparation of Venlafaxine Hydrochloride Sustained-release Tablets and Release Behavior in Vitro |
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| LIANG Wei,ZHOU Jian-ping,YU Yang.Preparation of Venlafaxine Hydrochloride Sustained-release Tablets and Release Behavior in Vitro[J].Progress in Pharmaceutical Sciences,2006,30(6):274-277. |
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| Authors: | LIANG Wei ZHOU Jian-ping YU Yang |
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| Institution: | Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Objective: To prepare venlafaxine hydrochloride sustained-release tablets and to evaluate release property in vitro.Methods: To prepare venlafaxine hydrochloride sustained-release tablets by orthogonal test.A method for determination of release in vitro has been established and the release rate of venlafaxine hydrochloride was determined by UV.Results: Venlafaxine hydrochloride sustained-release tablets have been prepared with 55% HPMC K100M.The release behavior is consistent with first kinetic equation.Conclusion: Venlafaxine hydrochloride sustained-release tablets prepared with 55% HPMC K100M have a better release behavior. |
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| Keywords: | Venlafaxine hydrochloride Sustained-release tablets Hydroxypropyl methyleellulese Release behavior |
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