Role of Nanotechnology in Erectile Dysfunction Treatment |
| |
| Affiliation: | 1. Department of Urology, University of Illinois at Chicago, Chicago, IL, USA;2. Departments of Urology, Physiology, and Bioengineering, University of Illinois at Chicago, Chicago, IL, USA;1. Division of Endocrinology, Department of Medicine, Michael Garron Hospital, Toronto, ON, Canada;2. Division of Endocrinology, Department of Medicine, Women''s College Hospital, Toronto, ON, Canada;1. Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, China;2. Department of Gynecology, The Second Hospital of Tianjin Medical University, Tianjin 300211, China;1. Department of Bioengineering, Materials Science and Engineering, Beckman Institute, University of Illinois Urbana-Champaign, Urbana, IL, USA;2. Mills Breast Cancer Institute, Carle Foundation Hospital, Urbana, IL, USA;3. Carle Illinois College of Medicine, Urbana, IL, USA;4. Ophthalmology Department, Carle Foundation Hospital, Urbana, IL, USA;5. Surgery Department, University of Illinois College of Medicine, Urbana, IL, USA;6. Interdisciplinary Health Science Initiative, University of Illinois, Urbana, IL, USA;1. Institut für Pharmazeutische Technologie, TU Braunschweig, Mendelssohnstr.1, 38106 Braunschweig, Germany;2. Institut für Partikeltechnik, TU Braunschweig, Volkmaroder Str. 5, 38104 Braunschweig, Germany;3. Institut für Mikrotechnik, TU Braunschweig, Alte Salzdahlumer Str. 203, 38124 Braunschweig, Germany |
| |
| Abstract: | IntroductionThe biological importance of nanotechnology-based delivery vehicles for in vivo tissue regeneration is gaining acceptance by the medical community; however, its relevance and incorporation into the treatment of sexual dysfunction are evolving and have not been well evaluated.AimTo provide scientific evidence examining the use of state-of-the-art nanotechnology-based delivery methodology in the treatment of erectile dysfunction (ED) in animal models and in patients.MethodsThis review assessed the current basic science literature examining the role of nanotechnology-based delivery vehicles in the development of potential ED therapies.ResultsThere are four primary areas where nanotechnology has been applied for ED treatment: (i) topical delivery of drugs for on-demand erectile function, (ii) injectable gels into the penis to prevent morphologic changes after prostatectomy, (iii) hydrogels to promote cavernous nerve regeneration or neuroprotection, and (iv) encapsulation of drugs to increase erectile function (primarily of phosphodiesterase type 5 inhibitors).ConclusionBasic science studies provide evidence for a significant and evolving role for nanotechnology in the development of therapies for ED and suggest that properly administered nano-based therapies might be advantageous for treating male sexual dysfunction. |
| |
| Keywords: | Nanotechnology Hydrogel Cavernous Nerve Penis Erectile Dysfunction |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
