Impact of length of red blood cells transfusion on postoperative delirium in elderly patients undergoing hip fracture surgery: A cohort study |
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| Affiliation: | 1. Department of Anesthesiology, People''s Hospital of Lishui County, Nanjing 211200, China;2. Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, China;3. Jiangsu Province Key Laboratory of Anaesthesiology, Xuzhou Medical College, Xuzhou, China;4. Jiangsu Province Key Laboratory of Anaesthesia and Analgesia Application Technology, Xuzhou, China;1. North Bristol NHS Trust, Bristol, United Kingdom;2. Stryker R&D Virtual Engineering, Kiel, Germany;1. Department of Orthopedics, Uppsala University, Uppsala, Sweden;2. Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden;1. Laboratory of Biomechanics, Justus-Liebig-University Giessen, Paul-Meimberg-Strasse 3, Giessen 35392, Germany;2. Laboratory for Biomechanics and Biomaterials (LBB), Department of Orthopaedic Surgery, Hannover Medical School, Anna-von-Borries-Strasse 1-7, Hannover 30628, Germany;3. Department of Orthopaedics and Orthopaedic Surgery, University Hospital Giessen and Marburg (UKGM), Klinikstrasse 33, Giessen 35392, Germany;4. Department of Orthopaedics and Traumatology, BG Trauma Centre Ludwigshafen, Ludwig-Guttmann-Strasse. 13, Ludwigshafen 67071, Germany;1. Clinic for Ortopaedic Surgery and Traumatology, Clinical Center of Serbia, Belgrade, Serbia;2. University of Belgrade – School of Medicine, Belgrade, Serbia;1. School of Engineering, University of British Columbia, Kelowna, Canada;2. AS Composite Inc., Pointe-Claire, Canada |
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| Abstract: | PurposeThe purpose of the present study was to test whether older red blood cells (RBCs) transfusion results in an increased risk of postoperative delirium (POD) and various in-hospital postoperative complications in elderly patients undergoing hip fracture surgery.Materials and methodsPatients (≥65 years) who underwent hip fracture surgery were enrolled, 179 patients were divided into two groups according to the storage time of the RBCs. The shorter storage time of RBCs transfusion group comprised patients who received RBCs ≤14 days old and the longer storage time of RBCs transfusion group comprised patients who received RBCs >14 days old. The blood samples were collected before anaesthesia induction, 4 and 24 h after RBCs transfusion for the determination of proinflammatory mediators, malondialdehyde, and superoxide dismutase activity.ResultsThere was no difference in the baseline characteristics, the incidence of POD, and the in-hospital postoperative complications between the shorter storage time of RBCs transfusion group and the longer storage time of RBCs transfusion groups (P > 0.05). Compared with the shorter storage time of RBCs transfusion group, the longer storage time of RBCs transfusion caused significantly longer duration of POD (P < 0.05). There were significantly increased plasma levels of IL-8 and malondialdehyde at 24 h and IL-1β at 4 h after RBCs transfusion in the POD group compared with the non-POD group (P < 0.05).ConclusionTransfusion of the longer storage RBCs is not associated with a higher incidence of POD or in-hospital postoperative complications, but with longer duration of POD in elderly patients undergoing hip fracture surgery. |
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| Keywords: | Postoperative delirium Length of red blood cells RBCs transfusion Elderly Hip fracture |
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