Immunofluorescence of Autoimmune Bullous Diseases |
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| Institution: | 2. Division of Infectious Diseases and Medical Microbiology, Hôpital Maisonneuve-Rosemont (HMR), CIUSSS de l''Est-de-l’Île-de-Montréal, Montreal, Que.;3. Department of Microbiology, Infectious Diseases and Immunology, Faculty of Medicine, Montreal, Que.;4. Department of Medical Microbiology and Infectious Diseases, Centre Hospitalier de l''Université de Montréal (CHUM), Montreal, Que.;5. Department of Ophthalmology, CUO-HMR, CIUSSS de l''Est-de-l’Île-de-Montréal, Montreal, Que.;11. Department of Social and Preventive Medicine, School of Public Health, Université de Montreal, Montreal, Que. |
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| Abstract: | Autoimmmune bullous diseases of skin and mucosa are uncommon, disabling, and potentially lethal diseases. For a quick and reliable diagnosis immunofluorescence is essential. This article describes two variants of immunofluorescence. The direct method uses a skin or mucosal biopsy of the patient to detect in vivo bound antibodies. Indirect immunofluorescence uses patient’s serum and a substrate to visualize circulating autoantibodies. These two methods supplemented with advanced techniques allow reliable classification of autoimmune bullous diseases; not only the main entities pemphigus and pemphigoid, but also subclasses within these groups. This is important because prognosis and therapy vary among different variants of autoimmune bullous diseases. |
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| Keywords: | Pemphigus Pemphigoid Immunofluorescence Autoimmune diseases |
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