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Laryngeal Dysplasia,Squamous Cell Carcinoma,and Variants
Affiliation:1. Department of Otolaryngology – Head and Neck Surgery, Centre Hospitalier Universitaire Vaudois (CHUV), University of Lausanne (UNIL), Rue Du Bugnon 21, 1011, Lausanne, Switzerland;2. European Organization for Research and Treatment of Cancer, Avenue E Mounier 83/1, 1200 Brussels, Belgium;3. Department of Radiation Oncology, Centre Léon Bérard, 28 Rue Laennec, 69373 Lyon, France;4. Department of Otorhinolaryngology – Head and Neck Surgery, Medical University of Graz, Auenbruggerplatz 26, A-8036 Graz, Austria;5. Department of Otorhinolaryngology – Head and Neck Surgery, Oulu University Hospital, Box 21, 90029 OYS, Finland;6. Department of Otolaryngology – Head and Neck Surgery, Centre Hospitalier Lyon Nord, 103 Grande Rue de La Croix Rousse, 69004 Lyon, France;7. Department of Otolaryngology Head and Neck Surgery, Humanitas University Milan, Via Rita Levi Montalcini, 4, 20090 Pieve Emanuele MI, Italy;8. Department of Otorhinolaryngology, University of Brescia, Piazza Spedali Civili 1, 25123, Brescia, Italy;9. Head and Neck Surgery and Medical Oncology, Department Fondazione IRCCS Istituto Tumori Milano and Università di Milano, Via Giacomo Venezian, 1, 20133 Milano, Italy;10. Department of Head and Neck Surgery, St Luc University Hospital and King Albert II Cancer Institute, 10 Ave Hippocrate, 1200 Brussels, Belgium;11. Department of Medical Oncology, St Luc University Hospital and King Albert II Cancer Institute, 10 Ave Hippocrate, 1200 Brussels, Belgium;12. Head & Neck Surgery Unit, St Luc University Hospital and King Albert II Cancer Institute, 10 Ave Hippocrate, 1200 Brussels, Belgium;13. Surgery Department, Centre des Tumeurs ULB, Institut Jules Bordet, Boulevard de Waterloo 121, 1000 Brussels, Belgium;14. Institute for Global Innovation and Institute of Head and Neck Studies and Education (InHANSE), Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK;15. Academic Unit of Oral Medicine, Pathology and Surgery, School of Clinical Dentistry, University of Sheffield, 19 Claremont Cres, Sheffield S10 2TA, UK;p. Department of Otolaryngology, Head and Neck Surgery, University Leipzig, Liebigstraße 12, 04103 Leipzig, Germany;q. Department of Otolaryngology – Head and Neck Surgery, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands;1. Department of Pathology, National Taiwan University Hospital, No 7, Chung-Shan South Road, Taipei 100, Taiwan;2. Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan;3. Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA;4. Department of Dentistry, National Taiwan University Hospital, No. 1, Changde Street, Zhongzheng District, Taipei City 100, Taiwan;5. Department of Dentistry, Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan;1. Voice Research Laboratory, Discipline of Speech Pathology, Faculty of Health Sciences, The University of Sydney, Lidcombe, New South Wales, Australia;2. Crown Princess Mary Cancer Care Centre, Westmead Hospital, Sydney, New South Wales, Australia;3. Department of Speech Pathology, Westmead Hospital, Sydney, New South Wales, Australia;4. Department of Otolaryngology Head Neck Surgery, Westmead Hospital, Sydney, New South Wales, Australia;1. Service d’ORL, CHU Farhat Hached, avenue Ibn Eljazzar, 4000 Sousse, Tunisia;2. Laboratoire d’anatomie et de cytologie pathologiques, CHU Farhat Hached, avenue Ibn Eljazzar, 4000 Sousse, Tunisia;1. Oral Medicine, Department of Diagnosis and Surgery, Araraquara Dental School, São Paulo State University (Unesp), Araraquara, São Paulo, Brazil;2. Oral Pathology, Department of Stomatology, Public Oral Health, and Forensic Dentistry, Ribeirão Preto Dental School (FORP/USP), University of São Paulo, Ribeirão Preto, SP, Brazil;3. Department of Dentistry, State University of Paraíba, Campina Grande, Paraíba, Brazil;4. Department of Pathology and Forensic Medicine, Ribeirão Preto Medical School (FMRP/USP), University of São Paulo, Ribeirão Preto, SP, Brazil
Abstract:Squamous cell carcinoma (SCC) is a malignant epithelial tumor showing evidence of squamous differentiation. It is the most common malignancy of the larynx, with several variants (verrucous, exophytic or papillary, spindle-cell, basaloid, acantholytic, adenosquamous) recognized, with well-established precursor lesions. Dysplasia is now separated into only low-grade and high-grade categories. Each SCC variant has unique cytomorphologic features and histologic differential diagnoses that are important to consider, as management and outcomes are different.
Keywords:Carcinoma, squamous cell  Carcinoma, adenosquamous  Carcinoma, verrucous  Larynx  Dysplasia
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