The Many Faces of Medication-Related Injury in the Gastrointestinal Tract |
| |
| Affiliation: | 1. Department of Pathology, University of Chicago, 5841 South Maryland Avenue, Chicago, IL, USA;2. Department of Pathology, University of Chicago, 5841 South Maryland Avenue, MC 6101, Chicago, IL, USA;1. Department of Surgery, Vanderbilt University Medical Center, Nashville, TN;2. Center for Quantitative Sciences, Vanderbilt University, Nashville, TN;3. Geriatric Research, Education, and Clinical Center, Tennessee Valley Healthcare System, Veterans Affairs Medical Center, Nashville, TN;1. Department of Oral and Maxillofacial Surgery, Sunderland Royal Hospital, Kayll Road, Sunderland SR4 7TP, United Kingdom;2. Centre for Oral Health Research, Newcastle University, Framlington Place, Newcastle Upon Tyne NE2 4BW, United Kingdom;1. Division of Otolaryngology, Department of Surgery, Zablocki VA Medical Center, 5000 National Ave, Milwaukee, WI 53296, USA;2. Department of Otolaryngology, Head & Neck Surgery, Oregon Health & Science University, 3181 Sam Jackson Park Rd, Portland, OR 97239, USA |
| |
| Abstract: | Every year many new medications are approved for clinical use, several of which can cause clinically significant gastrointestinal tract toxicity. This article emphasizes the histologic features and differential diagnosis of drug-induced injury to the gastrointestinal mucosa. Ultimately, clinical correlation and cessation of a drug with resolution of symptoms are needed to definitively confirm a drug as a causative factor in mucosal injury. Recognizing histologic features in gastrointestinal biopsies, however, can allow surgical pathologists to play a key role in establishing a diagnosis of drug-induced gastrointestinal toxicity. |
| |
| Keywords: | Gastrointestinal tract Drug toxicity Chemotherapy Immunomodulator Pathologic features |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
