Prenatal and postnatal administration of prebiotics and probiotics |
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| Institution: | 1. Newborn Services, The Royal Women''s Hospital, Parkville, Australia;2. Department of Obstetrics and Gynaecology, University of Melbourne, Parkville, Australia;3. Department of Paediatrics, University of Melbourne, Parkville, Australia;4. Clinical Sciences, Murdoch Children''s Research Centre, Parkville, Australia;1. Division of Neonatal Perinatal Medicine, MedStar Georgetown University Hospital, Washington DC, USA;2. Department of Obstetrics and Gynecology, MedStar Washington Hospital Center, Washington DC, USA;1. Department of Neonatology and Paediatrics, Joondalup Health Campus and Joondalup Child Development Centre, Joondalup, Western Australia, Australia;2. Department of Neonatology, King Edward Memorial Hospital for Women, Perth, Western Australia, Australia;3. Department of Neonatology, Princess Margaret Hospital for Children, Perth, Western Australia, Australia;4. Centre for Neonatal Research and Education, University of Western Australia, Australia |
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| Abstract: | Colonization of the neonatal gut by beneficial bacteria is important for the establishment and maintenance of the mucosal barrier, thus protecting the neonate from enteric pathogens and local and systemic inflammation. The neonatal microbiome is influenced by infant diet, environment, and the maternal microbiome. Dysbiosis in pregnancy increases the risk of pre-eclampsia, diabetes, infection, preterm labor, and later childhood atopy. Dysbiosis of the neonatal gut plays an important role in colic in the term infant, in the disease processes which plague preterm infants, including necrotizing enterocolitis and sepsis, and in the long-term outcomes of neonates. Administration of enteral prebiotics, probiotics, and synbiotics during pregnancy, lactation, and postnatal life appears to be a safe and feasible method to alter the maternal and neonatal microbiome, thus improving pregnancy and neonatal outcomes. |
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| Keywords: | Pregnancy Microbiota Prematurity Necrotizing enterocolitis Atopic dermatitis Allergic rhinitis Metabolic syndrome Diabetes mellitus |
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