1-［1-(6-甲氧基-2-萘基)乙基］-2-(4-硝基苄基)-6,7-二甲氧基-1,2,3,4-四氢异喹啉氢溴酸盐的光降解产物研究

研究1-［1-(6-甲氧基-2-萘基)乙基］-2-(4-硝基苄基)-6,7-二甲氧基-1,2,3,4-四氢异喹啉氢溴酸盐(编号P91024)遇光后颜色变暗的光降解产物。采用HPLC-MS及波谱分析鉴定光降解产物的化学结构，并经有机反应合成对照验证。P91024光降解的3个主要产物分别为溴化N-(4-硝基苄基)-6,7-二甲氧基-3,4-二氢异喹啉、1-［1-(6-甲氧基-2-萘基)乙基］-6,7-二甲氧基-1,2,3,4-四氢异喹啉和2-异丙基-6-甲氧基萘。

Photo-degradation products of 1-[1-(6-methoxy-2-naphthyl)ethyl]-2-(4-nitrobenzyl)-6,7-dimethoxyl-1,2,3,4-tetrahydroisoquinoline hydrobromide

To study the photo-degradation products of 1-1-(6-methoxy-2-naphthyl)ethyl]-2-(4-nitrobenzyl)-6,7-dimethoxyl-1,2,3,4-tetrahydroisoquinoline hydrobromide(code designation: P91024).The chemical structures of the major photo-degradation products of P91024 were identified by HPLC-MS and spectroscopic methods,and their reference substances were also synthesized for confirmation.The three major photo-degradation products were identified to be N-(4-nitrobenzyl)-6,7-dimethoxyl-3,4-dihydroisoquinoline bromide,1-1-(6-methoxyl-2-naphthyl)ethyl]-6,7-dimethoxyl-1,2,3,4-tetrahydroisoquinoline and 2-isopropyl-6-methoxyl-naphthalene,respectively.