一类新型的抗炎镇痛药物——一氧化氮供体型非甾体抗炎药一类新型的抗炎镇痛药物——一氧化氮供体型非甾体抗炎药

传统的非甾体抗炎药(NSAIDs)和环氧化酶-2(COX-2)选择性抑制剂临床应用极为广泛，但严重的胃肠道和新近发现的心血管不良反应限制了它们进一步的应用。一氧化氮(NO)供体型NSAIDs (NO-NSAIDs)的研发是近年来减少NSAIDs和COX-2选择性抑制剂不良反应的重要策略，此类药物既具有NSAIDs的抗炎、镇痛作用，又具有NO介导的胃肠道和心血管保护作用。本文简要介绍NO-NSAIDs的化学，重点综述NO-NSAIDs的药理特点、作用机制以及一些潜在的治疗应用。

A novel class of anti-inflammatory and analgesic drugs——NO-donating NSAIDs

Traditional non-steroidal anti-inflammatory drugs(NSAIDs) and COX-2 selective inhibitors are among the most widely used drugs.However,their significant side effects in gastrointestinal and cardiovascular systems limited the use of these drugs.Recently,research and development of NO-donating NSAIDs(NO-NSAIDs) have become one of the most important strategies to reduce these side effects.NO-NSAIDs may exert a broad range of positive effects in terms of NO-mediated gastrointestinal and cardiovascular safety as well as comparable or increased anti-inflammatory,analgesic properties relative to NSAIDs.This review briefly deals with chemistry of NO-NSAIDs,more details are focused on biological significance,mechanism of action,and therapeutic potential of this novel class of drugs.