| 地胆草倍半萜内酯化合物的结构修饰 |
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| 引用本文： | 梁侨丽,闵知大.地胆草倍半萜内酯化合物的结构修饰[J].药学学报,2007,42(11):1159-1161. |
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| 作者姓名： | 梁侨丽 闵知大 |
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| 作者单位： | 1. 南京中医药大学,药学院,江苏,南京,210046
2. 中国药科大学,中药学院,江苏,南京,210009 |
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| 摘 要： | 为寻找毒性低、活性强的化合物，对地胆草倍半萜内酯化合物进行结构修饰。本文首先从地胆草全草中分离得到去氧地胆草内酯(deoxyelephantopin)和地胆草种内酯(scabertopin)，再对这两个化合物进行氧化和氢化反应，制备不同结构修饰产物。共得到5个大环化合物，通过IR、 1H NMR和MS等方法确定其结构。其中4个化合物(2～5)为新化合物，部分化合物有一定的抗肿瘤活性。
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| 关 键 词： | 地胆草 倍半萜内酯 结构修饰 抗肿瘤活性 |
| 文章编号： | 0513-4870（2007）11-1159-03 |
| 收稿时间： | 2007-05-28 |
| 修稿时间： | 2007-05-28 |
Structure modification on sesquiterpene lactones from Elephantopus scaber |
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| LIANG Qiao-li,MIN Zhi-da.Structure modification on sesquiterpene lactones from Elephantopus scaber[J].Acta Pharmaceutica Sinica,2007,42(11):1159-1161. |
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| Authors: | LIANG Qiao-li MIN Zhi-da |
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| Institution: | 1. Nanjing University of Chinese Medicine, Nanjing 210046, China; 2. China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | In order to look for lower toxic and strongly active compounds,the structure of sesquiterpene lactones from Elephantopus scaber was modified.Deoxyelephantopin and scabertopin were isolated from the whole plant of Elephantopus scaber and hydrogenated and epoxidated.Five sesquiterpenoide derivatives were prepared and their structures were identified by IR,NMR and MS spectra analysis.Four sesquiterpenoides are new compounds.Part of the compounds show definite antitumor activity. |
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| Keywords: | Elephantopus scaber sesquiterpenoides structure modification antitumor activity |
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