|
|||||
|
|
| 多壁碳纳米管与甘草苷和异甘草苷的选择性吸附作用 | |
| 引用本文： | 韩博,李晴暖,吴胜伟,李俊纲,陈文,李文新.多壁碳纳米管与甘草苷和异甘草苷的选择性吸附作用[J].药学学报,2007,42(11):1222-1226. |
| 作者姓名： | 韩博 李晴暖 吴胜伟 李俊纲 陈文 李文新 |
| 作者单位： | 1. 中国科学院,上海应用物理研究所,纳米医药研究室,上海,201800;兵团教育部共建新疆特种植物药资源重点实验室,新疆,石河子,832002 2. 中国科学院,上海应用物理研究所,纳米医药研究室,上海,201800 3. 兵团教育部共建新疆特种植物药资源重点实验室,新疆,石河子,832002 |
| 基金项目： | 国家自然科学基金;国家重点基础研究发展计划(973计划) |
| 摘 要： | 碳纳米管作为一种特殊的纳米材料,具有中空结构,高强度韧性及良好的化学和热力学稳定性。对人体毒性小,有良好的生物相容性,一直被期望作为药物传送系统的运输载体1~4]。在碳纳米管与生物体系相互作用研究中发现碳纳米管是一种高效地向细胞内输送药物的载体。沈海军5]利用MM |
| 关 键 词： | 多壁碳纳米管 甘草苷 异甘草苷 选择性吸附 |
| 文章编号： | 0513-4870（2007）11-1222-05 |
| 收稿时间： | 2007-06-26 |
| 修稿时间： | 2007-06-26 |
Selective adsorption of multi-walled carbon nanotubes with liquiritin and isoliquiritin |
|
| HAN Bo,LI Qing-nuan,WU Sheng-wei,LI Jun-gang,CHEN Wen,LI Wen-xin.Selective adsorption of multi-walled carbon nanotubes with liquiritin and isoliquiritin[J].Acta Pharmaceutica Sinica,2007,42(11):1222-1226. | |
| Authors: | HAN Bo LI Qing-nuan WU Sheng-wei LI Jun-gang CHEN Wen LI Wen-xin |
| Institution: | 1. Laboratory of Nano-Biology and Medicine, Shanghai Institute of Applied Physics, Chinese Academy of Science, Shanghai 201800, China; 2. Key Laboratory of Xinjiang Phytomedicine Resources of Ministry of Education, Shihezi 832002, China |
| Abstract: | Selective adsorption of active ingredients liquiritin and isoliquiritin from Glycyrrhiza uralensis Fisch with multi-walled carbon nanotubes(MWNTs) has been studied.Distribution coefficients of liquiritin between ethanol solvent and r-MWNTs or o-MWNTs in 293K is 37.5 and 43.3,while the distribution coefficients of isoliquiritin between ethanol solvent and r-MWNTs or o-MWNTs is 717 and 1080,respectively.It was indicated that the distribution coefficient of isoliquiritin adsorbed by MWNTs was much larger than that of liquiritin,and oxidation treatment of MWNTs could obviously enhance their adsorption ability.The possible reasons that MWNTs can selectively adsorb isoliquiritin other than liquiritin were discussed on the bases of molecular structure of the active ingredients and their interaction with nanotubes. |
| Keywords: | multi-walled carbon nanotube liquiritin isoliquiritin selective adsorption |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
| 点击此处可从《药学学报》浏览原始摘要信息 | |
| 点击此处可从《药学学报》下载免费的PDF全文 | |