木豆叶芪类提取物对雌激素缺乏性大鼠骨质丢失的影响

植物雌激素具有雌激素的抗骨丢失的作用，却没有雌激素的不良反应，因而受到广泛的重视。各国科学家都在积极寻找安全有效的、具有雌激素样作用的天然产物。已经发现的这类植物雌激素有异黄酮、木酚素、香豆素、二苯乙烯类等，在多种植物和中草药中均含有这些化合物。

Effects of the stilbene extracts from Cajanus cajan L. on ovariectomy-induced bone loss in rats

The Cajanus cajan L. is a natural plant, which contains lots of potential active components. The effects of the stilbene extracts from Cajanus cajan L. (sECC) on ovariectomy (OVX)-induced bone loss in rats were identified. All experimental female rats were divided into 6 groups, i. e. sham-operated rats, OVX rats, 17beta-estradiol (E2)-treated rats, sECC-treated rats with three dosages, 50, 100, and 200 mg x kg(-1), separately. Two weeks after the operation, different dosage of sECC, E2 or deionized water were given to the 6 groups of rats, respectively for another 8 weeks through stomach. Then, all rats were killed. The body weight and uterus wet weight were measured. Contents of serum E2, follicle stimulating hormone (FSH), and luteinizing hormone (LH) were measured by radioimmunoassay. Femoral morphology was observed by HE stain. The results showed that there were no changes of the uterine weight and serum E2 concentration in sECC-treated rats compared with OVX rats. However, the serum FSH and LH concentrations reduced by 11.5% and 15.2% (P < 0.05), respectively. By HE staining, it is found that the 60% of the femur structure had been significantly improved in OVX rats treated with 200 mg x kg(-1) of sECC. The trabeculae were thicker and larger than that of OVX rats. It is clear that sECC improved femoral morphological structure and decreased FSH and LH contents without affecting serum E2 level and uterine weight in OVX rats. The results suggested that sECC had potential action in treatment of postmenopausal osteoporosis.