Blockade of 3-carbomethoxy-β-carboline induced seizures by diazepam and the benzodiazepine antagonists,Ro 15-1788 and CGS 8216 |
| |
| Authors: | Margaret Schweri Michael Cain James Cook Steven Paul Phil Skolnick |
| |
| Affiliation: | 1. Laboratory of Bioorganic Chemistry, NIADDK, USA;2. Neuroscience Branch, NIMH National Institutes of Health, Bethesda, MD 20205, USA;3. Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, WI 53201, USA |
| |
| Abstract: | The benzodiazepine antagonists Ro 15-1788 and CGS 8216 blocked the clonic and tonic convulsions elicited by 3-carbomethoxy-β-carboline (β-CCM). The PD50 values for Ro 15-1788, CGS 8216, and diazepam were: 2.0, 0.6, and 2.0 mg/kg, respectively. Neither Ro 15-1788 nor CGS 8216 potentiated the effect of a threshold convulsant dose of β-CCM. Moreover, these benzodiazepine antagonists neither attenuated nor potentiated the tremorigenic actions of another β-carboline, harmaline. Diazepam, however, considerably reduced the tremorigenic actions of this drug. |
| |
| Keywords: | Ro 15-1788 CGS 8216 3-Carbomethoxy-β-carboline Benzodiazepine antagonists |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
