Ethanol intoxication as function of genotype dependent responses in three inbred mice strains |
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| Authors: | Stephen F.A. Elston Kenneth Blum Leonard DeLallo Arthur H. Briggs |
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| Affiliation: | Division of Substance and Alcohol Misuse, Department of Pharmacology University of Texas Health Science Center, San Antonio, TX 78284, USA |
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| Abstract: | Three strains of mice, ICR Swiss, DBA/2J and C57B1/6J were compared for initial sensitivity, recovery from intoxication, and acute tolerance development to ethanol. The C57B1/6J mice were found to be less sensitive and to recover more rapidly from the effects of the same dose of ethanol than the other two strains treated. None of the strains tested demonstrated acute tolerance to ethanol when given the same dose 3 hours later. |
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| Keywords: | Ethanol intoxication Genotype responses Inbred mice |
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